| Tag | Content |
|---|
| CPLM ID | CPLM-007975 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Carnitine O-acetyltransferase |
Protein Synonyms/Alias | Carnitine acetylase; Carnitine acetyltransferase; CAT; CrAT |
Gene Name | Crat |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 195 | DSVVNFLKSKRPPTH | acetylation | [1] | | 261 | NHRNTWAKAYNNLIK | acetylation | [1] | | 268 | KAYNNLIKDKVNRES | acetylation | [1] | | 390 | FNITPEIKNDIEKAK | acetylation | [1] | | 395 | EIKNDIEKAKQNLSI | acetylation | [1] | | 609 | RMAHYLEKALLDMRT | acetylation | [1] |
|
Reference | [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome. Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ. Mol Cell. 2013 Jan 10;49(1):186-99. [ PMID: 23201123] |
Functional Description | Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria. |
Sequence Annotation | REGION 418 430 Coenzyme A binding (By similarity).
MOTIF 624 626 Microbody targeting signal (Potential).
ACT_SITE 343 343 Proton acceptor.
BINDING 452 452 Carnitine.
BINDING 454 454 Carnitine.
BINDING 455 455 Coenzyme A.
BINDING 465 465 Carnitine.
MOD_RES 261 261 N6-acetyllysine (By similarity).
MOD_RES 268 268 N6-acetyllysine (By similarity). |
Keyword | 3D-structure; Acetylation; Acyltransferase; Complete proteome; Endoplasmic reticulum; Fatty acid metabolism; Lipid metabolism; Membrane; Mitochondrion; Mitochondrion inner membrane; Peroxisome; Reference proteome; Transferase; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 626 AA |
Protein Sequence | MLAFAARTVV KPLGLLKPSS LMKVSGRFKA HQDALPRLPV PPLQQSLDYY LKALQPIVSE 60
EEWAHTKQLV DEFQTSGGVG ERLQKGLERR AKKMENWLSE WWLKTAYLQF RQPVVIYSSP 120
GVILPKQDFV DLQGQLRFAA KLIEGVLDFK SMIDNETLPV EFLGGQPLCM NQYYQILSSC 180
RVPGPKQDSV VNFLKSKRPP THITVVHNYQ FFELDVYHSD GTPLTSDQIF VQLEKIWNSS 240
LQSNKEPVGI LTSNHRNTWA KAYNNLIKDK VNRESVNSIQ KSIFTVCLDK QVPRVSDDVY 300
RNHVAGQMLH GGGSKFNSGN RWFDKTLQFI VAEDGSCGMV YEHAAAEGPP IVALVDHVME 360
YTKKPELVRS PMVPLPMPKK LRFNITPEIK NDIEKAKQNL SIMIQDLDIM MLTFHHFGKD 420
FPKSEKLSPD AFIQVALQLA YYRIYGQACA TYESASLRMF HLGRTDTIRS ASIDSLAFVK 480
GMGDSTVPEQ QKVELLRKAV QAHRAYTDRA IRGEAFDRHL LGLKLQAIED LVSMPDIFMD 540
TSYAIAMHFN LSTSQVPAKT DCVMFFGPVV PDGYGICYNP MEAHINFSVS AYNSCAETNA 600
ARMAHYLEKA LLDMRTLLQN HPRAKL 626 |
Gene Ontology | GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell. GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. GO:0005739; C:mitochondrion; IDA:MGI. GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell. GO:0004092; F:carnitine O-acetyltransferase activity; IEA:EC. GO:0019254; P:carnitine metabolic process, CoA-linked; IEA:Compara. GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW. GO:0006810; P:transport; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |