CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040561
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Ubiquitin carboxyl-terminal hydrolase 
Protein Synonyms/Alias
  
Gene Name
 Usp32 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
589RPVIKNSKTDIPELEubiquitination[1]
951EKYTGLKKQLSDLCGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 Calcium; Complete proteome; Hydrolase; Metal-binding; Protease; Reference proteome; Repeat; Thiol protease; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1604 AA 
Protein Sequence
MGAKESRIGF LSYEEALRRV TDVELKRLKD AFKRTCGLSY YMSQHCFIRE VLGDGVPPKV 60
AEVIYCSFGG TSKGLHFNNL IVGLVLLTRG KDEEKAKYIF SLFSSESGSY VVREEMERML 120
HVVDGKVPDT LRKCFSEGEK VNYEKFRNWL LLNKDAFTFS RWLLSGGVYV TLTDDSDTPT 180
FYQTLAGVTH LEESDIIDLE KRYWLLKAQS RTGRFDLETF GPLVSPPIRP SLSEGLFNAF 240
DENRDNHIDF KEISCGLSAC CRGPLAERQK FCFKVFDVDR DGVLSRVELK DMVVALLEVW 300
KDNRTDDIPE LHMDLSDIVE RILNAHDTTK VGHLTLEDYQ IWSVKNVLAN EFLNLLFQVC 360
HIVLGLRPAT PEEEGQIIRG WLERESRYGL QPGHNWFIIS MQWWQQWKEY VKYDASPVVI 420
EPSSVLNGGK FSFGTAAHPI EHGEDRISNN LGYMNTTEEK YSDNISSASE ASESTGSGFL 480
YSGTPGADMC FARQHNTSDN NNQCLLGANG NILLHLNPQK PGAIDNQPLV TQEPVKATSL 540
TLEGGRLKRT PQLIHGRDYE MVPEPVWRAL YHWYGSNLAL PRPVIKNSKT DIPELELFPR 600
YLLFLRQQPA TRTQQSNIWV NMGNVPSPNA PLKRVLAYTG CFSRMQTIKE IHEYLSQRLR 660
IKEEDMRLWL YNSENYLTLL DDEDHRLEYL KIQDEQHLVI EVRNKDMSWP EEMSFIANSS 720
KIDRHKVPTE KGATGLSNLG NTCFMNSSIQ CVSNTQPLTQ YFISGRHLYE LNRTNPIGMK 780
GHMAKCYGDL VQELWSGTQK NVAPLKLRWT IAKYAPRFNG FQQQDSQELL AFLLDGLHED 840
LNRVHEKPYV ELKDSDGRPD WEVAAEAWDN HLRRNRSIVV DLFHGQLRSQ VKCKTCGHIS 900
VRFDPFNFLS LPLPMDSYMH LEITVIKLDG TTPIRYGLRL NMDEKYTGLK KQLSDLCGLK 960
SEQILFAEVH SSNIKNFPQD NQKVRLSVSG FLCAFEIPIP ASPVSACSPI QTDCSSSPST 1020
NGLFTLTTNG DLPRPIFIPN GMPNTVVPCG TEKNVTNGIV NGHMPPLPDD PFTGYIIAVH 1080
RKMMRTELYF LSSQKNRPSL FGMPLIVPCT VHTRKKDLYD AVWIQVSRLA SPLPPQEASN 1140
HAQDCDDSMG YQYPFTLRVV QKDGNSCAWC PWYRFCRGCK IDCGEDRAFI GNACIAVDWD 1200
PTALHLRYQT SQERVVEEHE SVEQSRRAQA EPINLDSCLR AFTSEEELGE NEMYYCSKCK 1260
THCLATKKLD LWRLPPILII HLKRFQFVNG RWIKSQKIVK FPRESFDPSA FLVPRDPTLC 1320
QHKPLTPQGD DFSELRIPAG DVKKVDIQSS AGEEDVLLSK SPSSLSANVT SSPKGSPSSS 1380
RKSGASCPSS KNSSPNSSPR TLGRNKGRLR LPQIGSKNKL SNSKENLDTS KENGAGQICE 1440
LADTLNRRHV LGGSQPELVT PLDHEITLAN GFLYEHEACG NGYSNGQLGN HSEEDSTDDQ 1500
REETHSKPIY NLYAISCHSG ILGGGHYVTY AKNPNCKWYC YNDSSCKELH PDEIDTDSAY 1560
ILFYEQQGID CAQFLPKTDG KKMADTSSMD EDFESDYKKY CVLQ 1604 
Gene Ontology
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
 GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.
 GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro. 
Interpro
 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom.
 IPR006615; Pept_C19_DUSP.
 IPR018200; Pept_C19ubi-hydrolase_C_CS.
 IPR001394; Peptidase_C19.
 IPR001125; Recoverin. 
Pfam
 PF06337; DUSP
 PF13202; EF_hand_3
 PF00443; UCH 
SMART
 SM00695; DUSP
 SM00054; EFh 
PROSITE
 PS51283; DUSP
 PS00018; EF_HAND_1
 PS50222; EF_HAND_2
 PS00972; UCH_2_1
 PS00973; UCH_2_2
 PS50235; UCH_2_3 
PRINTS
 PR00450; RECOVERIN.