CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024599
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 S-formylglutathione hydrolase 
Protein Synonyms/Alias
 FGH; Esterase D 
Gene Name
 Esd 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
4****MELKQISSNKCacetylation[1]
198YLGPDQSKWKAYDATacetylation[1]
200GPDQSKWKAYDATCLacetylation[1]
278DHIRHHAKYLNA***acetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Serine hydrolase involved in the detoxification of formaldehyde (By similarity). 
Sequence Annotation
 ACT_SITE 149 149 Charge relay system (By similarity).
 ACT_SITE 226 226 Charge relay system (By similarity).
 ACT_SITE 260 260 Charge relay system (By similarity).
 MOD_RES 200 200 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Hydrolase; Reference proteome; Serine esterase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 282 AA 
Protein Sequence
MELKQISSNK CFGGLQKVFE HSSVELKCKM KFAIYLPPQA ESAKCPALYW LSGLTCTEQN 60
FISKSGCQQA ASEHGLVVIA PDTSPRGCNI KGEDDSWDFG TGAGFFVNAT EDPWNTNYRM 120
YSYVTEELPQ LINANFPVDP QRISIFGHSM GGHGALICAL KNPGKYRSVS AFAPICNPVL 180
CPWGKKAFNG YLGPDQSKWK AYDATCLVKS YSGPQIDILI DQGKDDEFLS NGQLLPDNFI 240
AACTEKKIPV VFRLQEGYDH SYYFIATFIT DHIRHHAKYL NA 282 
Gene Ontology
 GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0004091; F:carboxylesterase activity; IEA:UniProtKB-KW.
 GO:0018738; F:S-formylglutathione hydrolase activity; IEA:EC.
 GO:0046294; P:formaldehyde catabolic process; IEA:InterPro. 
Interpro
 IPR000801; Esterase_put.
 IPR014186; S-formylglutathione_hydrol. 
Pfam
 PF00756; Esterase 
SMART
  
PROSITE
  
PRINTS