CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014748
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Folliculin-interacting protein 1 
Protein Synonyms/Alias
  
Gene Name
 Fnip1 
Gene Synonyms/Alias
 Kiaa1961 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
161PPQLMLSKVFTARTGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 (By similarity). 
Sequence Annotation
 MOD_RES 593 593 Phosphoserine (By similarity).
 MOD_RES 594 594 Phosphoserine (By similarity).
 MOD_RES 760 760 Phosphoserine (By similarity).
 MOD_RES 763 763 Phosphoserine (By similarity).
 MOD_RES 907 907 Phosphoserine.  
Keyword
 Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1165 AA 
Protein Sequence
MAPTLFQKLF SKRSGLGAPG RDARDPDCAF SWPLPEFDPS QIRLIVYQDC ERRGRNVLFD 60
SSVKRKNEDT SVSKLCNDAQ VKVFGKCCQL KPGGDSSSSL DSSITLSSDG KDQCPKYQGS 120
RCSSDANMLG EMMFGSVAMS YKGSTLKIHQ IRSPPQLMLS KVFTARTGSS ICGSLNTLQD 180
SLEFINQDSN TLKADSSTVS NGLLGNIGLS QFCSPRRAFS EQGPLRLIRS ASFFAVHSNP 240
MDMPGRELNE DRDSGIARSA SLSSLFITPF PSPNSSLTRS CASSYQRRWR RSQTTSLENG 300
VFPRWSVEES FNLSDESCGP NPGIVRKKKI AIGVIFSLSK DEDENNKFNE FFFSHFPLFE 360
SHMNKLKSAI EQAMKMSRRS ADASQRSLAY NRILDALTEF RTTICNLYTM PRIGEPVWLT 420
MMSGTPEKNQ LCHRFMKEFT FLMENASKNQ FLPALITAVL TNHLAWVPTV MPNGQPPIKI 480
FLEKHSSQSV GMLAKTHPYN PLWAQLGDLY GAIGSPVRLA RTVVVGKRQD LVQRLLYFLT 540
YFIRCSELQE THLLENGEDE AIVMPGTVIT TTLEKGEIEE SEYVLITMHR NKSSLLFKES 600
EETRTPNCNC KYCSHPVLGQ NTENVSQPER EDTQDNSKEL LGISDECQKI SPPDCQEENA 660
VDVQQYRDKL RTCLDTKLET VVCTGSAPAD KCVLSETCLE PREESWQNKE LLDSDNHTGT 720
AMRPTGIVVE KKPPDKNVPS AFSCEVTQTK VTFLIGDSMS PDSDTELRSQ AVVDQINRHH 780
SEPLKEDRGV ADKHQESKIT KDQSEDSDTQ NIVSGESCEL PCWSHSDPES MSLFDEYFND 840
DSIETRTIDD VPVKTSTDSK EYCCMLEYPK RLYTKTNKQK SELCKCIETV HQDSCNACFP 900
QQDQRNSLSI LVPHGDKESS DKKNAVGTEW DIPRNESSDS ALGDSESEDT GPDIRRQAGG 960
YCGGDQEDWT EEDEIPFPGS KLIEVSAVQP NIANFGRSLL GGYCSSYVPD FVLQGIGNDE 1020
RLRQCLVSDL SHAVQHPVLD EPIAEAVCII ADMDKWTVQV ASSQRRVTDN KLGKEVLVSS 1080
LVSNLLHSTL QLYKHNLSPN FCVMHLEDRL QELYFKSKML SEYLRGQMRV HVKELGVVLG 1140
IESSDLPLLA AVASTHSPYV AQILL 1165 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005085; F:guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
 GO:0009267; P:cellular response to starvation; IMP:MGI.
 GO:0002327; P:immature B cell differentiation; IMP:MGI.
 GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:MGI.
 GO:0032007; P:negative regulation of TOR signaling cascade; IMP:MGI.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
 GO:0002904; P:positive regulation of B cell apoptotic process; IMP:MGI.
 GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Compara.
 GO:0001934; P:positive regulation of protein phosphorylation; ISS:UniProtKB.
 GO:2000973; P:regulation of pro-B cell differentiation; IMP:MGI.
 GO:0031929; P:TOR signaling cascade; ISS:UniProtKB. 
Interpro
 IPR026156; FNIP_fam. 
Pfam
  
SMART
  
PROSITE
  
PRINTS
 PR02073; FOLLICULNIP1.