CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001398
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ganglioside-induced differentiation-associated protein 1 
Protein Synonyms/Alias
 GDAP1 
Gene Name
 Gdap1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
173NTESELKKLAEENPDubiquitination[1]
188LQEAYIAKQKRLKSKubiquitination[1]
207DNVKYLKKILDELEKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Regulates the mitochondrial network by promoting mitochondrial fission (By similarity). 
Sequence Annotation
 DOMAIN 24 105 GST N-terminal.
 DOMAIN 153 309 GST C-terminal.
 REGION 320 358 Required for mitochondrial localization
 MOD_RES 203 203 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Direct protein sequencing; Membrane; Mitochondrion; Mitochondrion outer membrane; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 358 AA 
Protein Sequence
MARRQDEARA GVPLRVEGPP DKEVHLILYH WTHSFSSQKV RLVIAEKALK CEEHDVSLPL 60
SEHNEPWFMR LNSAGEVPVL VHGENIICEA TQIIDYLEQT FLDERTPRLM PDEGSMYYPR 120
VQHYRELLDS LPMDAYTHGC ILHPELTVDS MIPAYATTRI RSQIGNTESE LKKLAEENPD 180
LQEAYIAKQK RLKSKLLDHD NVKYLKKILD ELEKVLDQVE TELQRRNEET PEEGNQPWLC 240
GESFTLADVS LAVTLHRLKF LGFARRNWGH GKRPNLETYY ERVLKRKTFN KVLGHVNNIL 300
ISAVLPTAFR VAKKRAPKVL GSTLVVGLLV GMGYFAFMLF RRRLGSMILA LRPRPNYF 358 
Gene Ontology
 GO:0031307; C:integral to mitochondrial outer membrane; ISS:UniProtKB.
 GO:0000266; P:mitochondrial fission; ISS:UniProtKB.
 GO:0006626; P:protein targeting to mitochondrion; ISS:UniProtKB.
 GO:0032526; P:response to retinoic acid; IDA:MGI. 
Interpro
 IPR010987; Glutathione-S-Trfase_C-like.
 IPR004045; Glutathione_S-Trfase_N.
 IPR017933; Glutathione_S_Trfase/Cl_chnl_C.
 IPR012336; Thioredoxin-like_fold. 
Pfam
  
SMART
  
PROSITE
 PS50405; GST_CTER
 PS50404; GST_NTER 
PRINTS