CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033850
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Bile acid receptor 
Protein Synonyms/Alias
  
Gene Name
 Nr1h4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
356LLEERIRKSGISDEYubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 474 AA 
Protein Sequence
MNLIGHSHLQ ATDEFSLSES LFGMLTEHAA GPLGQNLDLE SYSPYNNVPF PQVQPQISSS 60
SYYSNLGFYP QQPEDWYSPG IYELRRMPAE TGYQGETEVS EMPVTKKPRM AAASAGRIKG 120
DELCVVCGDR ASGYHYNALT CEGCKGFFRR SITKNAVYKC KNGGNCVMDM YMRRKCQECR 180
LRKCKEMGML AECMYTGLLT EIQCKSKRLR KNVKQHADQT ANEDDSEGRD LRQVTSTTKF 240
CREKTELTAD QQTLLDYIMD SYNKQRMPQE ITNKILKEEF SAEENFLILT EMATSHVQIL 300
VEFTKKLPGF QTLDHEDQIA LLKGSAVEAM FLRSAEIFNK KLPAGHADLL EERIRKSGIS 360
DEYITPMFSF YKSVGELKMT QEEYALLTAI VILSPDRQYI KDREAVEKLQ EPLLDVLQKL 420
CKMYQPENPQ HFACLLGRLT ELRTFNHHHA EMLMSWRVND HKFTPLLCEI WDVQ 474 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-KW.
 GO:0046965; F:retinoid X receptor binding; IDA:MGI.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IGI:MGI.
 GO:0003707; F:steroid hormone receptor activity; IEA:InterPro.
 GO:0004887; F:thyroid hormone receptor activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0008206; P:bile acid metabolic process; IMP:MGI.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IGI:MGI. 
Interpro
 IPR008946; Nucl_hormone_rcpt_ligand-bd.
 IPR000536; Nucl_hrmn_rcpt_lig-bd_core.
 IPR001723; Str_hrmn_rcpt.
 IPR001728; ThyrH_rcpt.
 IPR001628; Znf_hrmn_rcpt.
 IPR013088; Znf_NHR/GATA. 
Pfam
 PF00104; Hormone_recep
 PF00105; zf-C4 
SMART
 SM00430; HOLI
 SM00399; ZnF_C4 
PROSITE
 PS00031; NUCLEAR_REC_DBD_1
 PS51030; NUCLEAR_REC_DBD_2 
PRINTS
 PR00398; STRDHORMONER.
 PR00047; STROIDFINGER.
 PR00546; THYROIDHORMR.