UniProt Accession

 MAX_RAT; P52164 

Genbank Protein ID

 D14447; D14448 

Genbank Nucleotide ID

 BAA03337.1; BAA03338.1 

Protein Name

 Protein max 

Protein Synonyms/Alias

 Myc-associated factor X 

Gene Name

 Max 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
66	SRAQILDKATEYIQY	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. 

Sequence Annotation

 DOMAIN 23 74 bHLH.
 REGION 81 102 Leucine-zipper.
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 2 2 Phosphoserine (By similarity).
 MOD_RES 11 11 Phosphoserine (By similarity).
 MOD_RES 153 153 N6-acetyllysine (By similarity).
 MOD_RES 154 154 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Activator; Alternative splicing; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 160 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:RGD.
 GO:0030425; C:dendrite; IDA:RGD.
 GO:0071339; C:MLL1 complex; ISS:UniProtKB.
 GO:0016605; C:PML body; IDA:RGD.
 GO:0032403; F:protein complex binding; IDA:RGD.
 GO:0042803; F:protein homodimerization activity; IDA:RGD.
 GO:0043565; F:sequence-specific DNA binding; IDA:RGD.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IMP:RGD.
 GO:0071375; P:cellular response to peptide hormone stimulus; IEP:RGD.
 GO:0009267; P:cellular response to starvation; IEP:RGD.
 GO:0010629; P:negative regulation of gene expression; IDA:RGD.
 GO:0051402; P:neuron apoptotic process; IEP:RGD.
 GO:0006461; P:protein complex assembly; IDA:RGD.
 GO:0048678; P:response to axon injury; IEP:RGD.
 GO:0032868; P:response to insulin stimulus; IEP:RGD.
 GO:0060041; P:retina development in camera-type eye; IEP:RGD.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR011598; bHLH_dom. 

Pfam

 PF00010; HLH 

SMART

 SM00353; HLH 

PROSITE

 PS50888; BHLH 

PRINTS