CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023574
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Caspase Nc 
Protein Synonyms/Alias
 NEDD2-like caspase DRONC; Caspase Nc subunit 1; Caspase Nc subunit 2 
Gene Name
 Nc 
Gene Synonyms/Alias
 CG8091 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
58NTQDLNGKPFNMDEKacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Involved in the activation cascade of caspases responsible for apoptosis execution. Effector of steroid-mediated apoptosis during insect metamorphosis. Overexpression promotes programmed cell death. Interaction with th is required to suppress Nc-mediated cell death; via th-mediated ubiquitination of Nc. Rate-limiting caspase in rpr and W death pathway. 
Sequence Annotation
 DOMAIN 64 109 CARD.
 REGION 114 125 Required for binding th.
 ACT_SITE 271 271 By similarity.
 ACT_SITE 318 318 By similarity.  
Keyword
 3D-structure; Apoptosis; Complete proteome; Cytoplasm; Hydrolase; Protease; Reference proteome; Thiol protease; Ubl conjugation; Zymogen. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 450 AA 
Protein Sequence
MQPPELEIGM PKRHREHIRK NLNILVEWTN YERLAMECVQ QGILTVQMLR NTQDLNGKPF 60
NMDEKDVRVE QHRRLLLKIT QRGPTAYNLL INALRNINCL DAAVLLESVD ESDSRPPFIS 120
LNERRTSRKS ADIVDTPSPE ASEGPCVSKL RNEPLGALTP YVGVVDGPEV KKSKKIHGGD 180
SAILGTYKMQ SRFNRGVLLM VNIMDYPDQN RRRIGAEKDS KSLIHLFQEL NFTIFPYGNV 240
NQDQFFKLLT MVTSSSYVQN TECFVMVLMT HGNSVEGKEK VEFCDGSVVD MQKIKDHFQT 300
AKCPYLVNKP KVLMFPFCRG DEYDLGHPKN QGNLMEPVYT AQEEKWPDTQ TEGIPSPSTN 360
VPSLADTLVC YANTPGYVTH RDLDTGSWYI QKFCQVMADH AHDTDLEDIL KKTSEAVGNK 420
RTKKGSMQTG AYDNLGFNKK LYFNPGFFNE 450 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:FlyBase.
 GO:0004197; F:cysteine-type endopeptidase activity; IDA:FlyBase.
 GO:0042803; F:protein homodimerization activity; IDA:FlyBase.
 GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:FlyBase.
 GO:0007417; P:central nervous system development; IMP:FlyBase.
 GO:0048749; P:compound eye development; IMP:FlyBase.
 GO:0048813; P:dendrite morphogenesis; IMP:FlyBase.
 GO:0008340; P:determination of adult lifespan; IMP:FlyBase.
 GO:0010623; P:developmental programmed cell death; IMP:FlyBase.
 GO:0008258; P:head involution; IMP:FlyBase.
 GO:0007516; P:hemocyte development; IMP:FlyBase.
 GO:0035081; P:induction of programmed cell death by hormones; TAS:FlyBase.
 GO:0008285; P:negative regulation of cell proliferation; IDA:FlyBase.
 GO:0016322; P:neuron remodeling; IMP:FlyBase.
 GO:0045476; P:nurse cell apoptotic process; IGI:FlyBase.
 GO:0046672; P:positive regulation of compound eye retinal cell programmed cell death; IMP:FlyBase.
 GO:0016540; P:protein autoprocessing; IDA:FlyBase.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
 GO:0035071; P:salivary gland cell autophagic cell death; IEP:FlyBase.
 GO:0007291; P:sperm individualization; IMP:FlyBase.
 GO:0031638; P:zymogen activation; IMP:FlyBase. 
Interpro
 IPR017350; Caspase_IL-1_beta.
 IPR011029; DEATH-like_dom.
 IPR011600; Pept_C14_cat.
 IPR001309; Pept_C14_ICE_p20.
 IPR016129; Pept_C14_ICE_p20_AS.
 IPR002138; Pept_C14_p10.
 IPR002398; Pept_C14_p45.
 IPR015917; Pept_C14_p45_core. 
Pfam
 PF00656; Peptidase_C14 
SMART
 SM00115; CASc 
PROSITE
 PS50209; CARD
 PS01122; CASPASE_CYS
 PS01121; CASPASE_HIS
 PS50207; CASPASE_P10
 PS50208; CASPASE_P20 
PRINTS
 PR00376; IL1BCENZYME.