CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011748
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ribosome biogenesis protein YTM1 
Protein Synonyms/Alias
 Microtubule-associated protein YTM1 
Gene Name
 YTM1 
Gene Synonyms/Alias
 YOR272W 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
35MYAPISLKRYGLSEIacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919
Functional Description
 Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. 
Sequence Annotation
 REPEAT 101 140 WD 1.
 REPEAT 142 180 WD 2.
 REPEAT 206 244 WD 3.
 REPEAT 285 325 WD 4.
 REPEAT 327 366 WD 5.
 REPEAT 373 413 WD 6.
 REPEAT 424 460 WD 7.
 REGION 99 460 Sufficient for interaction with ERB1 and  
Keyword
 Complete proteome; Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 460 AA 
Protein Sequence
MTEDKSQVKI RFFTREKDEL LHVQDTPMYA PISLKRYGLS EIVNHLLGSE KPVPFDFLIE 60
GELLRTSLHD YLTKKGLSSE ASLNVEYTRA ILPPSYLNSF SNEDWVSSLD VGDGSKHIIS 120
GSYDGIVRTW DLSGNVQKQY SGHSGPIRAV KYISNTRLVS AGNDRTLRLW KTKNDDLKLT 180
SQQQAQEDDD DEVNIEDGKT LAILEGHKAP VVSIDVSDNS RILSASYDNS IGFWSTIYKE 240
MTVVDPLEDI NNPNNKISTA ARKRRKLTMK DGTIRRRAPL SLLESHTAPV EQVIFDSTDN 300
TVGYSVSQDH TIKTWDLVTA RCIDTRTTSY SLLSIAQLST LNLLACGSSA RHITLHDPRV 360
GASSKVTQQQ LIGHKNFVSS LDTCPENEYI LCSGSHDGTV KVWDVRSTSP MYTITREDKS 420
VQKGVNDKVF AVKWAEKVGI ISAGQDKKIQ INKGDNIFKN 460 
Gene Ontology
 GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
 GO:0070545; C:PeBoW complex; IDA:SGD.
 GO:0030687; C:preribosome, large subunit precursor; IDA:SGD.
 GO:0051276; P:chromosome organization; IGI:SGD.
 GO:0042273; P:ribosomal large subunit biogenesis; IPI:SGD.
 GO:0006364; P:rRNA processing; IEA:UniProtKB-KW. 
Interpro
 IPR020472; G-protein_beta_WD-40_rep.
 IPR012972; NLE.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF08154; NLE
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS
 PR00320; GPROTEINBRPT.