UniProt Accession

 THIOM_MOUSE; P97493; A2A440; Q545D5 

Genbank Protein ID

 U85089; AK002358; AK010917; AK147164; AK149855; AK167754; AK167925; AK168322; AL583886; BC068182 

Genbank Nucleotide ID

 AAB41900.1; BAB22037.1; BAB27267.1; BAE27729.1; BAE29126.1; BAE39789.1; BAE39930.1; BAE40261.1; CAM23427.1; AAH68182.1 

Protein Name

 Thioredoxin, mitochondrial 

Protein Synonyms/Alias

 MTRX; Mt-Trx; Thioredoxin-2 

Gene Name

 Txn2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
102	ILGPRLEKMVAKQHG	acetylation	[1]
110	MVAKQHGKVVMAKVD	acetylation	[1]
152	VDKFVGIKDEDQLEA	acetylation	[1]
162	DQLEAFLKKLIG***	acetylation	[1]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane potential (By similarity). Possesses a dithiol-reducing activity. 

Sequence Annotation

 DOMAIN 61 166 Thioredoxin.
 ACT_SITE 90 90 Nucleophile (By similarity).
 ACT_SITE 93 93 Nucleophile (By similarity).
 MOD_RES 152 152 N6-acetyllysine (By similarity).
 DISULFID 90 93 Redox-active (By similarity).  

Keyword

 Acetylation; Complete proteome; Disulfide bond; Electron transport; Mitochondrion; Redox-active center; Reference proteome; Transit peptide; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 166 AA 

Protein Sequence

Gene Ontology

 GO:0030425; C:dendrite; IEA:Compara.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0015035; F:protein disulfide oxidoreductase activity; IEA:InterPro.
 GO:0045454; P:cell redox homeostasis; IEA:InterPro.
 GO:0031669; P:cellular response to nutrient levels; IEA:Compara.
 GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
 GO:0006662; P:glycerol ether metabolic process; IEA:InterPro.
 GO:0048678; P:response to axon injury; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0009749; P:response to glucose stimulus; IEA:Compara.
 GO:0009725; P:response to hormone stimulus; IEA:Compara.
 GO:0001666; P:response to hypoxia; IEA:Compara.
 GO:0007584; P:response to nutrient; IEA:Compara.
 GO:0014070; P:response to organic cyclic compound; IEA:Compara.
 GO:0006979; P:response to oxidative stress; IEA:Compara. 

Interpro

 IPR005746; Thioredoxin.
 IPR012336; Thioredoxin-like_fold.
 IPR017937; Thioredoxin_CS.
 IPR013766; Thioredoxin_domain. 

Pfam

 PF00085; Thioredoxin 

SMART

  

PROSITE

 PS00194; THIOREDOXIN_1
 PS51352; THIOREDOXIN_2 

PRINTS

 PR00421; THIOREDOXIN.