CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020040
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial 
Protein Synonyms/Alias
 Protein SITPEC 
Gene Name
 ECSIT 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
138QLLNIFPKEVFRPRNubiquitination[1]
201MLKLVRLKLWFPRFMubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development (By similarity). 
Sequence Annotation
  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Immunity; Innate immunity; Mitochondrion; Nucleus; Polymorphism; Reference proteome; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 431 AA 
Protein Sequence
MSWVQATLLA RGLCRAWGGT CGAALTGTSI SQVPRRLPRG LHCSAAAHSS EQSLVPSPPE 60
PRQRPTKALV PFEDLFGQAP GGERDKASFL QTVQKFAEHS VRKRGHIDFI YLALRKMREY 120
GVERDLAVYN QLLNIFPKEV FRPRNIIQRI FVHYPRQQEC GIAVLEQMEN HGVMPNKETE 180
FLLIQIFGRK SYPMLKLVRL KLWFPRFMNV NPFPVPRDLP QDPVELAMFG LRHMEPDLSA 240
RVTIYQVPLP KDSTGAADPP QPHIVGIQSP DQQAALARHN PARPVFVEGP FSLWLRNKCV 300
YYHILRADLL PPEEREVEET PEEWNLYYPM QLDLEYVRSG WDNYEFDINE VEEGPVFAMC 360
MAGAHDQATM AKWIQGLQET NPTLAQIPVV FRLAGSTREL QTSSAGLEEP PLPEDHQEED 420
DNLQRQQQGQ S 431 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0005667; C:transcription factor complex; IEA:Compara.
 GO:0016651; F:oxidoreductase activity, acting on NAD(P)H; IDA:UniProtKB.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0004871; F:signal transducer activity; IEA:Compara.
 GO:0030509; P:BMP signaling pathway; IEA:Compara.
 GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
 GO:0001707; P:mesoderm formation; IEA:Compara.
 GO:0051341; P:regulation of oxidoreductase activity; IDA:UniProtKB. 
Interpro
 IPR010418; ECSIT. 
Pfam
 PF06239; ECSIT 
SMART
  
PROSITE
  
PRINTS