CPLM-020635

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-020635

UniProt Accession

NUP37_MOUSE; Q9CWU9; Q9CZ80

Genbank Protein ID

AK010370; AK012890; AK040463; AK165537; CH466539; CH466539; CH466539; BC011102; BC032180

Genbank Nucleotide ID

BAB26888.1; BAB28538.1; BAC30597.1; BAE38243.1; EDL21469.1; EDL21470.1; EDL21471.1; AAH11102.1; AAH32180.1

Protein Name

Nucleoporin Nup37

Protein Synonyms/Alias

Nup107-160 subcomplex subunit Nup37

Gene Name

Nup37

Gene Synonyms/Alias

Created Date

July 27, 2013

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Lysine Modification

Position	Peptide	Type	References
114	FTSDLQDKNEYKVLE	ubiquitination	[1]

Reference

[1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]

Functional Description

Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation (By similarity).

Sequence Annotation

REPEAT 70 117 WD 1.
REPEAT 122 162 WD 2.
REPEAT 164 203 WD 3.
REPEAT 294 325 WD 4.

Keyword

Cell cycle; Cell division; Centromere; Chromosome; Chromosome partition; Complete proteome; Kinetochore; Mitosis; mRNA transport; Nuclear pore complex; Nucleus; Protein transport; Reference proteome; Repeat; Translocation; Transport; WD repeat.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

326 AA

Protein Sequence

MKQDATRNAA YTVDCEDYVH VVEFNPFESG DSGNLIAYGG SNYVVVGMCT FQEEETDIEG 60
IQYKTLRTFH HGVRVDGIAW SPETKLDSLP PVIKFCTSAA DLKIRLFTSD LQDKNEYKVL 120
EGHSDFINDL VFHPKEGQEL ASVSDDHTCR IWNLEGKQTA HFLLHSPGMS VCWHPEETFK 180
LMVAEKNGTI RFYDLMAQQA ILSLQSEQTP LMSAHWCLKN TFKVGAVAGN DWIIWDITRS 240
SYPQETRPVH MDRAHLFRWS AISENLFATT GYPGKMASQF QIHHLGHSQP VLIGSVAVGS 300
GLSWHRTLPL CAVGGDHKLL FWVTEI 326

Gene Ontology

GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.
GO:0031080; C:nuclear pore outer ring; IEA:Compara.
GO:0051301; P:cell division; IEA:UniProtKB-KW.
GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
GO:0007067; P:mitosis; IEA:UniProtKB-KW.
GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
GO:0015031; P:protein transport; IEA:UniProtKB-KW.

Interpro

IPR015943; WD40/YVTN_repeat-like_dom.
IPR001680; WD40_repeat.
IPR019775; WD40_repeat_CS.
IPR017986; WD40_repeat_dom.

Pfam

PF00400; WD40

SMART

SM00320; WD40

PROSITE

PS00678; WD_REPEATS_1
PS50082; WD_REPEATS_2
PS50294; WD_REPEATS_REGION

PRINTS