UniProt Accession

 PERT_HUMAN; P07202; P09934; P09935; Q8IUL0; Q8NF94; Q8NF95; Q8NF96; Q8NF97; Q8TCI9 

Genbank Protein ID

 J02969; J02970; Y00406; M25715; M25702; M25703; M25704; M25705; M25706; M25707; M25708; M25709; M25710; M25711; M25712; M25713; M25714; X17358; M17755; AF439430; AF533528; AY136822; AF533529; AF533530; AF533531; M55702; M55702 

Genbank Nucleotide ID

 AAA61215.1; AAA61216.1; CAA68467.1; AAA97517.1; AAA97517.1; AAA97517.1; AAA97517.1; AAA97517.1; AAA97517.1; AAA97517.1; AAA97517.1; AAA97517.1; AAA97517.1; AAA97517.1; AAA97517.1; AAA97517.1; AAA97517.1; CAA35235.1; AAA61217.2; AAL74416.1; AAN04471.1; AAN11302.1; AAN04472.1; AAN04473.1; AAN04474.1; AAA61219.1; AAA61218.1 

Protein Name

 Thyroid peroxidase 

Protein Synonyms/Alias

 TPO 

Gene Name

 TPO 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
879	RWTRTGTKSTLPISE	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4). 

Sequence Annotation

 DOMAIN 740 795 Sushi.
 DOMAIN 796 839 EGF-like; calcium-binding (Potential).
 ACT_SITE 239 239 Proton acceptor (By similarity).
 METAL 240 240 Calcium (By similarity).
 METAL 321 321 Calcium (By similarity).
 METAL 323 323 Calcium; via carbonyl oxygen (By
 METAL 325 325 Calcium (By similarity).
 METAL 327 327 Calcium (By similarity).
 METAL 494 494 Iron (heme axial ligand) (By similarity).
 BINDING 238 238 Heme (covalent; via 2 links) (By
 BINDING 399 399 Heme (covalent; via 2 links) (By
 CARBOHYD 129 129 N-linked (GlcNAc...) (Potential).
 CARBOHYD 307 307 N-linked (GlcNAc...) (Potential).
 CARBOHYD 342 342 N-linked (GlcNAc...) (Potential).
 CARBOHYD 569 569 N-linked (GlcNAc...) (Potential).
 DISULFID 142 158 By similarity.
 DISULFID 259 269 By similarity.
 DISULFID 263 286 By similarity.
 DISULFID 598 655 By similarity.
 DISULFID 696 721 By similarity.
 DISULFID 800 814 By similarity.
 DISULFID 808 823 By similarity.
 DISULFID 825 838 By similarity.  

Keyword

 Alternative splicing; Calcium; Complete proteome; Congenital hypothyroidism; Disease mutation; Disulfide bond; EGF-like domain; Glycoprotein; Heme; Hydrogen peroxide; Iron; Membrane; Metal-binding; Oxidoreductase; Peroxidase; Polymorphism; Reference proteome; Signal; Sushi; Thyroid hormones biosynthesis; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 933 AA 

Protein Sequence

Gene Ontology

 GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0004447; F:iodide peroxidase activity; IEA:EC.
 GO:0004601; F:peroxidase activity; TAS:ProtInc.
 GO:0034641; P:cellular nitrogen compound metabolic process; TAS:Reactome.
 GO:0035162; P:embryonic hemopoiesis; IDA:DFLAT.
 GO:0042446; P:hormone biosynthetic process; IEA:UniProtKB-KW.
 GO:0042744; P:hydrogen peroxide catabolic process; IEA:UniProtKB-KW.
 GO:0006590; P:thyroid hormone generation; TAS:Reactome. 

Interpro

 IPR000742; EG-like_dom.
 IPR001881; EGF-like_Ca-bd.
 IPR013032; EGF-like_CS.
 IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
 IPR018097; EGF_Ca-bd_CS.
 IPR010255; Haem_peroxidase.
 IPR002007; Haem_peroxidase_animal.
 IPR019791; Haem_peroxidase_animal_subgr.
 IPR000436; Sushi_SCR_CCP. 

Pfam

 PF03098; An_peroxidase
 PF07645; EGF_CA 

SMART

 SM00032; CCP
 SM00179; EGF_CA 

PROSITE

 PS00010; ASX_HYDROXYL
 PS00022; EGF_1
 PS01186; EGF_2
 PS50026; EGF_3
 PS01187; EGF_CA
 PS00435; PEROXIDASE_1
 PS00436; PEROXIDASE_2
 PS50292; PEROXIDASE_3
 PS50923; SUSHI 

PRINTS

 PR00457; ANPEROXIDASE.