CPLM 1.0 - Compendium of Protein Lysine Modification
Tag
Content
CPLM ID
CPLM-038425
UniProt Accession
E9Q3Z4_MOUSE
;
E9Q3Z4
Genbank Protein ID
AC154610
Genbank Nucleotide ID
Protein Name
Hexokinase-3
Protein Synonyms/Alias
Gene Name
Hk3
Gene Synonyms/Alias
Created Date
July 27, 2013
Organism
Mus musculus (Mouse)
NCBI Taxa ID
10090
Lysine Modification
Position
Peptide
Type
References
129
STLISWT
K
GFRCSGV
ubiquitination
[1]
735
ARDIFKT
K
FLSEIES
ubiquitination
[1]
Reference
[1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [
PMID: 22790023
]
Functional Description
Sequence Annotation
Keyword
ATP-binding; Complete proteome; Glycolysis; Kinase; Nucleotide-binding; Reference proteome; Transferase.
Sequence Source
UniProt (SWISSPROT/TrEMBL); GenBank; EMBL
Protein Length
867 AA
Protein Sequence
MEQALKGQDS PAPSVRMLPT YVRSTPHGTE QGDFLVLELG ATGASLRVLW VTLTGTKECR 60
VEPRSREFVI PQEVILGAGQ QLFDFAARCL SEFLDAYPVE NQGLKLGFNF SFPCHQTGLD 120
RSTLISWTKG FRCSGVEGQD VVQLLRDAIQ RQGTYRIDVV AMVNDTVGTM MGCELGTRPC 180
EVGLIVDTGT NACYMEEARH VAALDEDRGR TCVSIEWGSF YDEDALGPVL TTFDSALDRE 240
SLTPGAQRFE KMIGGLYLGE LVRLVLVHLT QHGVLFDGCA SPALLSQGCI LLDHVAEMED 300
TATGTARVHT ILQDLGLSPR ASDAELVQYV CVAVCTRAAQ LCAAALAAVL SRLQHSREQQ 360
TLQVAVATGG RVFERHPRFL RILKETVTLL APNCDVSFIP SVDGGGRGVA MVTAVAARLA 420
AHRRILEETL APFQLTLEQM TVVQAQMREA MIRGLQGEAS SLRMLPTYVR ATPDGSERGD 480
FLALDLGGTN FRVLLVRVAE GSVQIINQVY SIPECRAQGS GQKLFDHIVD CIVDFQKRQG 540
LSGQSLPLGF TFSFPCKQLG LDQGILLNWT KGFNASGCEG QDVVYLLREA IRRRQAVELN 600
VVAIVNDTVG TMMSCGYDDP RCEMGLIVGT GTNACYMEEL RNVASVPGDS GLMCINMEWG 660
AFGDDGSLGT LSTRFDTSVD QASINPGKQR FEKMISGMYL GEIVRHILLH LTNLGVLFRG 720
QKTQCLQARD IFKTKFLSEI ESDSLALRQV RAILEDLGLT LTSDDALMVL EVCQAVSRRA 780
AQLCGAGVAA VVEKIRENRG LQELTVSVGV DGTLYKLHPH FSKLVSATVR KLAPQCTVTF 840
LQSEDGSGKG AALVTAVACR LTQMAHV 867
Gene Ontology
GO:0005829
; C:cytosol; IBA:RefGenome.
GO:0005739
; C:mitochondrion; IDA:MGI.
GO:0043234
; C:protein complex; IEA:Compara.
GO:0005524
; F:ATP binding; IEA:UniProtKB-KW.
GO:0008865
; F:fructokinase activity; IBA:RefGenome.
GO:0004340
; F:glucokinase activity; IBA:RefGenome.
GO:0042562
; F:hormone binding; IEA:Compara.
GO:0019158
; F:mannokinase activity; IBA:RefGenome.
GO:0001678
; P:cellular glucose homeostasis; IBA:RefGenome.
GO:0006096
; P:glycolysis; IBA:RefGenome.
Interpro
IPR001312
; Hexokinase.
IPR022673
; Hexokinase_C.
IPR019807
; Hexokinase_CS.
IPR022672
; Hexokinase_N.
Pfam
PF00349
; Hexokinase_1
PF03727
; Hexokinase_2
SMART
PROSITE
PS00378
; HEXOKINASES
PRINTS
PR00475
; HEXOKINASE.