CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002609
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 S-arrestin 
Protein Synonyms/Alias
 48 kDa protein; Retinal S-antigen; S-AG; Rod photoreceptor arrestin; S-arrestin short form 
Gene Name
 SAG 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Bos taurus (Bovine) 
NCBI Taxa ID
 9913 
Lysine Modification
Position
Peptide
Type
References
2******MKANKPAPNacetylation[1]
5***MKANKPAPNHVIacetylation[1]
28SVTIYLGKRDYIDHVacetylation[1]
163STDVEEDKIPKKSSVacetylation[1]
166VEEDKIPKKSSVRLLacetylation[1]
167EEDKIPKKSSVRLLIacetylation[1]
176SVRLLIRKVQHAPRDacetylation[1]
201WQFFMSDKPLRLAVSacetylation[1]
211RLAVSLSKEIYYHGEacetylation[1]
232AVTNSTEKTVKKIKVacetylation[1]
235NSTEKTVKKIKVLVEacetylation[1]
236STEKTVKKIKVLVEQacetylation[1]
238EKTVKKIKVLVEQVTacetylation[1]
267AAEEAQEKVPPNSSLacetylation[1]
276PPNSSLTKTLTLVPLacetylation[1]
298RGIALDGKIKHEDTNacetylation[1]
300IALDGKIKHEDTNLAacetylation[1]
367PEDPDTAKESFQDENacetylation[1]
386EFARQNLKDAGEYKEacetylation[1]
392LKDAGEYKEEKTDQEacetylation[1]
395AGEYKEEKTDQEAAMacetylation[1]
Reference
 [1] Topographic study of arrestin using differential chemical modifications and hydrogen/deuterium exchange.
 Ohguro H, Palczewski K, Walsh KA, Johnson RS.
 Protein Sci. 1994 Dec;3(12):2428-34. [PMID: 7756996] 
Functional Description
 Arrestin is one of the major proteins of the ros (retinal rod outer segments); it binds to photoactivated- phosphorylated rhodopsin, thereby apparently preventing the transducin-mediated activation of phosphodiesterase. Isoform B plays a role in the phototransduction cascade. 
Sequence Annotation
 MOD_RES 1 1 N-acetylmethionine; partial.
 MOD_RES 230 230 Phosphothreonine (By similarity).
 DISULFID 128 143 Probable.  
Keyword
 3D-structure; Acetylation; Alternative splicing; Autoimmune uveitis; Calcium; Complete proteome; Direct protein sequencing; Disulfide bond; Phosphoprotein; Reference proteome; Sensory transduction; Vision. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 404 AA 
Protein Sequence
MKANKPAPNH VIFKKISRDK SVTIYLGKRD YIDHVERVEP VDGVVLVDPE LVKGKRVYVS 60
LTCAFRYGQE DIDVMGLSFR RDLYFSQVQV FPPVGASGAT TRLQESLIKK LGANTYPFLL 120
TFPDYLPCSV MLQPAPQDVG KSCGVDFEIK AFATHSTDVE EDKIPKKSSV RLLIRKVQHA 180
PRDMGPQPRA EASWQFFMSD KPLRLAVSLS KEIYYHGEPI PVTVAVTNST EKTVKKIKVL 240
VEQVTNVVLY SSDYYIKTVA AEEAQEKVPP NSSLTKTLTL VPLLANNRER RGIALDGKIK 300
HEDTNLASST IIKEGIDKTV MGILVSYQIK VKLTVSGLLG ELTSSEVATE VPFRLMHPQP 360
EDPDTAKESF QDENFVFEEF ARQNLKDAGE YKEEKTDQEA AMDE 404 
Gene Ontology
 GO:0007165; P:signal transduction; IEA:InterPro.
 GO:0007601; P:visual perception; IEA:UniProtKB-KW. 
Interpro
 IPR000698; Arrestin.
 IPR011021; Arrestin-like_N.
 IPR014752; Arrestin_C.
 IPR011022; Arrestin_C-like.
 IPR017864; Arrestin_CS.
 IPR014753; Arrestin_N.
 IPR014756; Ig_E-set. 
Pfam
 PF02752; Arrestin_C
 PF00339; Arrestin_N 
SMART
 SM01017; Arrestin_C 
PROSITE
 PS00295; ARRESTINS 
PRINTS
 PR00309; ARRESTIN.