UniProt Accession

 GPC1_MOUSE; Q9QZF2 

Genbank Protein ID

 AF185613; BC062902 

Genbank Nucleotide ID

 AAD56243.1; AAH62902.1 

Protein Name

 Glypican-1 

Protein Synonyms/Alias

 Secreted glypican-1 

Gene Name

 Gpc1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
376	PSTGTLEKLVSEAKA	acetylation	[1]
376	PSTGTLEKLVSEAKA	succinylation	[1]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling. Binds Cu(2+) or Zn(2+) ions. 

Sequence Annotation

 LIPID 529 529 GPI-anchor amidated serine (Potential).
 CARBOHYD 79 79 N-linked (GlcNAc...).
 CARBOHYD 116 116 N-linked (GlcNAc...).
 CARBOHYD 485 485 O-linked (Xyl...) (heparan sulfate)
 CARBOHYD 487 487 O-linked (Xyl...) (heparan sulfate)
 CARBOHYD 489 489 O-linked (Xyl...) (heparan sulfate)
 DISULFID 32 68 By similarity.
 DISULFID 62 255 By similarity.
 DISULFID 69 258 By similarity.
 DISULFID 190 342 By similarity.
 DISULFID 245 278 By similarity.
 DISULFID 267 414 By similarity.
 DISULFID 271 400 By similarity.  

Keyword

 Cell membrane; Complete proteome; Copper; Disulfide bond; Endosome; Glycoprotein; GPI-anchor; Heparan sulfate; Lipoprotein; Membrane; Proteoglycan; Reference proteome; S-nitrosylation; Secreted; Signal; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 557 AA 

Protein Sequence

Gene Ontology

 GO:0031225; C:anchored to membrane; IEA:UniProtKB-KW.
 GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
 GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
 GO:0005796; C:Golgi lumen; TAS:Reactome.
 GO:0045121; C:membrane raft; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005578; C:proteinaceous extracellular matrix; IDA:UniProtKB.
 GO:0005507; F:copper ion binding; ISS:UniProtKB.
 GO:0017134; F:fibroblast growth factor binding; IDA:UniProtKB.
 GO:0043236; F:laminin binding; IDA:UniProtKB.
 GO:0030200; P:heparan sulfate proteoglycan catabolic process; ISS:UniProtKB.
 GO:0032288; P:myelin assembly; ISS:UniProtKB.
 GO:0040037; P:negative regulation of fibroblast growth factor receptor signaling pathway; IDA:UniProtKB.
 GO:2001016; P:positive regulation of skeletal muscle cell differentiation; IEP:UniProtKB.
 GO:0014037; P:Schwann cell differentiation; ISS:UniProtKB. 

Interpro

 IPR001863; Glypican.
 IPR015502; Glypican-1.
 IPR019803; Glypican_CS. 

Pfam

 PF01153; Glypican 

SMART

  

PROSITE

 PS01207; GLYPICAN 

PRINTS