UniProt Accession

 GNAS2_RAT; P63095; P04894; P08755; Q05087; Q45QM7; Q9Z1R8 

Genbank Protein ID

 M12673; M17525; L10326; AF107844; DQ120475; DQ120476; BC061967 

Genbank Nucleotide ID

 AAA41261.1; AAA40827.1; AAA41664.1; AAD11802.1; AAZ23814.1; AAZ23815.1; AAH61967.1 

Protein Name

 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short 

Protein Synonyms/Alias

 Adenylate cyclase-stimulating G alpha protein; G-alpha-8 

Gene Name

 Gnas 

Gene Synonyms/Alias

 Gnas1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
186	LDKIDVIKQADYVPS	ubiquitination	[1]

Reference

 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. 

Sequence Annotation

 NP_BIND 47 54 GTP (By similarity).
 NP_BIND 198 204 GTP (By similarity).
 NP_BIND 223 227 GTP (By similarity).
 NP_BIND 292 295 GTP (By similarity).
 METAL 54 54 Magnesium (By similarity).
 METAL 204 204 Magnesium (By similarity).
 BINDING 366 366 GTP; via amide nitrogen (By similarity).
 MOD_RES 51 51 Phosphoserine (By similarity).
 MOD_RES 352 352 Phosphoserine (By similarity).
 LIPID 2 2 N-palmitoyl glycine (By similarity).
 LIPID 3 3 S-palmitoyl cysteine.
 CROSSLNK 300 300 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Alternative splicing; Cell membrane; Complete proteome; GTP-binding; Isopeptide bond; Lipoprotein; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Palmitate; Phosphoprotein; Reference proteome; Transducer; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 394 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:BHF-UCL.
 GO:0005768; C:endosome; IDA:RGD.
 GO:0005834; C:heterotrimeric G-protein complex; IDA:BHF-UCL.
 GO:0045121; C:membrane raft; IDA:RGD.
 GO:0001726; C:ruffle; IDA:RGD.
 GO:0031982; C:vesicle; IDA:RGD.
 GO:0043014; F:alpha-tubulin binding; IDA:RGD.
 GO:0031681; F:G-protein beta-subunit binding; IDA:RGD.
 GO:0031683; F:G-protein beta/gamma-subunit complex binding; IBA:RefGenome.
 GO:0005525; F:GTP binding; IDA:RGD.
 GO:0003924; F:GTPase activity; IBA:RefGenome.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0031852; F:mu-type opioid receptor binding; IDA:RGD.
 GO:0004871; F:signal transducer activity; IDA:RGD.
 GO:0007191; P:adenylate cyclase-activating dopamine receptor signaling pathway; IDA:BHF-UCL.
 GO:0055074; P:calcium ion homeostasis; IMP:RGD.
 GO:0071870; P:cellular response to catecholamine stimulus; IDA:BHF-UCL.
 GO:0071380; P:cellular response to prostaglandin E stimulus; IDA:BHF-UCL.
 GO:0045776; P:negative regulation of blood pressure; IMP:RGD.
 GO:0035814; P:negative regulation of renal sodium excretion; IMP:RGD.
 GO:0030819; P:positive regulation of cAMP biosynthetic process; IMP:RGD.
 GO:0001934; P:positive regulation of protein phosphorylation; IMP:RGD.
 GO:0010765; P:positive regulation of sodium ion transport; IMP:RGD.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IMP:RGD.
 GO:0007606; P:sensory perception of chemical stimulus; IBA:RefGenome. 

Interpro

 IPR000367; Gprotein_alpha_S.
 IPR001019; Gprotein_alpha_su.
 IPR011025; GproteinA_insert.
 IPR027417; P-loop_NTPase. 

Pfam

 PF00503; G-alpha 

SMART

 SM00275; G_alpha 

PROSITE

  

PRINTS

 PR00318; GPROTEINA.
 PR00443; GPROTEINAS.