CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004587
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 THO complex subunit HPR1 
Protein Synonyms/Alias
 Hyperrecombination protein 1 
Gene Name
 HPR1 
Gene Synonyms/Alias
 YDR138W; YD9302.14 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
171ESNLISYKQPLYEKLacetylation[1]
558VYEAAQAKWESKISSacetylation[1]
683QTEGDELKSEQTQPKubiquitination[2]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Component the THO subcomplex of the TREX complex, which operates in coupling transcription elongation to mRNA export. The THO complex is recruited to transcribed genes and moves along the gene with the elongating polymerase during transcription. THO is important for stabilizing nascent RNA in the RNA polymerase II elongation complex by preventing formation of DNA:RNA hybrids behind the elongating polymerase. It functions in cotranscriptional formation of an export-competent messenger ribonucleoprotein particle (mRNP) by facilitating the loading of ATP-dependent RNA helicase SUB2 and the mRNA export factor YRA1 along the nascent mRNA. 
Sequence Annotation
 MOD_RES 234 234 Phosphoserine.
 MOD_RES 675 675 Phosphoserine; by ATM or ATR.  
Keyword
 Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 752 AA 
Protein Sequence
MSNTEELIQN SIGFLQKTFK ALPVSFDSIR HEPLPSSMLH ASVLNFEWEP LEKNISAIHD 60
RDSLIDIILK RFIIDSMTNA IEDEEENNLE KGLLNSCIGL DFVYNSRFNR SNPASWGNTF 120
FELFSTIIDL LNSPSTFLKF WPYAESRIEW FKMNTSVEPV SLGESNLISY KQPLYEKLRH 180
WNDILAKLEN NDILNTVKHY NMKYKLENFL SELLPINEES NFNRSASISA LQESDNEWNR 240
SARERESNRS SDVIFAADYN FVFYHLIICP IEFAFSDLEY KNDVDRSLSP LLDAILEIEE 300
NFYSKIKMNN RTRYSLEEAL NTEYYANYDV MTPKLPVYMK HSNAMKMDRN EFWANLQNIK 360
ESDDYTLRPT IMDISLSNTT CLYKQLTQED DDYYRKQFIL QLCFTTNLIR NLISSDETRN 420
FYKSCYLREN PLSDIDFENL DEVNKKRGLN LCSYICDNRV LKFYKIKDPD FYRVIRKLMS 480
SDEKFTTAKI DGFKEFQNFR ISKEKIPPPA FDETFKKFTF IKMGNKLINN VWKIPTGLDK 540
IEQEVKKPEG VYEAAQAKWE SKISSETSGG EAKDEIIRQW QTLRFLRSRY LFDFDKVNEK 600
TGVDGLFEEP RKVEALDDSF KEKLLYKINQ EHRKKLQDAR EYKIGKERKK RALEEEASFP 660
EREQKIKSQR INSASQTEGD ELKSEQTQPK GEISEENTKI KSSEVSSQDP DSGVAGEFAP 720
QNTTAQLENP KTEDNNAATS NISNGSSTQD MK 752 
Gene Ontology
 GO:0000446; C:nucleoplasmic THO complex; IMP:SGD.
 GO:0000445; C:THO complex part of transcription export complex; IPI:SGD.
 GO:0003676; F:nucleic acid binding; IDA:SGD.
 GO:0032947; F:protein complex scaffold; IMP:SGD.
 GO:0006310; P:DNA recombination; IMP:SGD.
 GO:0031124; P:mRNA 3'-end processing; IMP:SGD.
 GO:0006406; P:mRNA export from nucleus; IMP:SGD.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006368; P:transcription elongation from RNA polymerase II promoter; IMP:SGD.
 GO:0006283; P:transcription-coupled nucleotide-excision repair; IMP:SGD. 
Interpro
 IPR021861; THO_THOC1. 
Pfam
 PF11957; efThoc1 
SMART
  
PROSITE
  
PRINTS