UniProt Accession

 A1AT_RAT; P17475; Q6AYZ5 

Genbank Protein ID

 D00675; BC078824; M32247; X16273 

Genbank Nucleotide ID

 BAA00579.1; AAH78824.1; AAA40788.1; CAA34349.1 

Protein Name

 Alpha-1-antiproteinase 

Protein Synonyms/Alias

 Alpha-1-antitrypsin; Alpha-1-proteinase inhibitor; Serpin A1 

Gene Name

 Serpina1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
140	GNGLFVNKNLKLVEK	acetylation	[1]
143	LFVNKNLKLVEKFLE	acetylation	[1]
147	KNLKLVEKFLEEVKN	acetylation	[1]
172	FADSEEAKKVINDYV	acetylation	[1]
173	ADSEEAKKVINDYVE	acetylation	[1]
181	VINDYVEKGTQGKIV	acetylation	[1]
186	VEKGTQGKIVDLMKQ	acetylation	[1]
213	IFFKGKWKRPFNPEH	acetylation	[1]
230	DADFHVDKSTTVKVP	acetylation	[1]
287	HLEQTLTKDLISRFL	acetylation	[1]
308	SAILYFPKLSISGTY	acetylation	[1]
353	KLSQAVHKAVLTLDE	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Inhibitor of serine proteases. The primary target is elastase, but also has a moderate affinity for plasmin and thrombin. 

Sequence Annotation

 REGION 367 386 RCL.
 CARBOHYD 64 64 N-linked (GlcNAc...) (Potential).
 CARBOHYD 101 101 N-linked (GlcNAc...) (Potential).
 CARBOHYD 265 265 N-linked (GlcNAc...) (Potential).  

Keyword

 Acute phase; Complete proteome; Direct protein sequencing; Glycoprotein; Protease inhibitor; Reference proteome; Secreted; Serine protease inhibitor; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 411 AA 

Protein Sequence

Gene Ontology

 GO:0005615; C:extracellular space; IDA:RGD.
 GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:RefGenome.
 GO:0006953; P:acute-phase response; IEA:UniProtKB-KW.
 GO:0006954; P:inflammatory response; IEP:RGD.
 GO:0030162; P:regulation of proteolysis; IBA:RefGenome.
 GO:0046687; P:response to chromate; IDA:RGD.
 GO:0034097; P:response to cytokine stimulus; IEP:RGD.
 GO:0032355; P:response to estradiol stimulus; IEP:RGD.
 GO:0001666; P:response to hypoxia; IEP:RGD.
 GO:0010288; P:response to lead ion; IDA:RGD.
 GO:0032496; P:response to lipopolysaccharide; IEP:RGD.
 GO:0033986; P:response to methanol; IDA:RGD.
 GO:0034014; P:response to triglyceride; IEP:RGD. 

Interpro

 IPR023795; Protease_inhib_I4_serpin_CS.
 IPR023796; Serpin_dom.
 IPR000215; Serpin_fam. 

Pfam

 PF00079; Serpin 

SMART

 SM00093; SERPIN 

PROSITE

 PS00284; SERPIN 

PRINTS