CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041994
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cold shock domain containing E1, RNA-binding, isoform CRA_d 
Protein Synonyms/Alias
 Cold shock domain-containing protein E1 
Gene Name
 CSDE1 
Gene Synonyms/Alias
 hCG_38456 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
127SSDRRTGKPIAVKLVubiquitination[1]
137AVKLVKIKQEILPEEubiquitination[1, 2]
212NFVIDNNKHTGAVSAubiquitination[3]
227RNIMLLKKKQARCQGubiquitination[1]
240QGVVCAMKEAFGFIEubiquitination[1]
253IERGDVVKEIFFHYSubiquitination[3]
285TIKDRNGKEVATDVRubiquitination[1, 3]
323VIPKVPSKNQNDPLPubiquitination[1, 3]
334DPLPGRIKVDFVIPKubiquitination[1]
353GDKDTKSKVTLLEGDubiquitination[1]
410RDGFGFIKCVDRDVRubiquitination[1, 3]
627VSAEKVNKTHSVNGIubiquitination[1]
646DPTIYSGKVIRPLRSubiquitination[1]
694NKGDCLQKGESVKFQubiquitination[1]
728RATVECVKDQFGFINubiquitination[1]
743YEVGDSKKLFFHVKEubiquitination[1]
775ILNQRTGKCSACNVWubiquitination[1, 3]
789WRVCEGPKAVAAPRPubiquitination[1]
804DRLVNRLKNITLDDAubiquitination[1, 3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 844 AA 
Protein Sequence
MENVFTVSSD PHPSPAAPPS LSLPLSSSST SSGTKKQKRT PTYQRSMSFD PNLLHNNGHN 60
GYPNGTSAAL RETGVIEKLL TSYGFIQCSE RQARLFFHCS QYNGNLQDLK VGDDVEFEVS 120
SDRRTGKPIA VKLVKIKQEI LPEERMNGQV VCAVPHNLES KSPAAPGQSP TGSVCYERNG 180
EVFYLTYTPE DVEGNVQLET GDKINFVIDN NKHTGAVSAR NIMLLKKKQA RCQGVVCAMK 240
EAFGFIERGD VVKEIFFHYS EFKGDLETLQ PGDDVEFTIK DRNGKEVATD VRLLPQGTVI 300
FEDISIEHFE GTVTKVIPKV PSKNQNDPLP GRIKVDFVIP KELPFGDKDT KSKVTLLEGD 360
HVRFNISTDR RDKLERATNI EVLSNTFQFT NEAREMGVIA AMRDGFGFIK CVDRDVRMFF 420
HFSEILDGNQ LHIADEVEFT VVPDMLSAQR NHAIRIKKLP KGTVSFHSHS DHRFLGTVEK 480
EATFSNPKTT SPNKGKEKEA EDGIIAYDDC GVKLTIAFQA KDVEGSTSPQ IGDKVEFSIS 540
DKQRPGQQVA TCVRLLGRNS NSKRLLGYVA TLKDNFGFIE TANHDKEIFF HYSEFSGDVD 600
SLELGDMVEY SLSKGKGNKV SAEKVNKTHS VNGITEEADP TIYSGKVIRP LRSVDPTQTE 660
YQGMIEIVEE GDMKGEVYPF GIVGMANKGD CLQKGESVKF QLCVLGQNAQ TMAYNITPLR 720
RATVECVKDQ FGFINYEVGD SKKLFFHVKE VQDGIELQAG DEVEFSVILN QRTGKCSACN 780
VWRVCEGPKA VAAPRPDRLV NRLKNITLDD ASAPRLMVLR QPRGPDNSMG FGAERKIRQA 840
GVID 844 
Gene Ontology
 GO:0005743; C:mitochondrial inner membrane; IEA:Compara.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro. 
Interpro
 IPR019844; Cold-shock_CS.
 IPR011129; Cold_shock_prot.
 IPR002059; CSP_DNA-bd.
 IPR012340; NA-bd_OB-fold.
 IPR024642; SUZ-C. 
Pfam
 PF00313; CSD
 PF12901; SUZ-C 
SMART
 SM00357; CSP 
PROSITE
 PS00352; COLD_SHOCK 
PRINTS