CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036627
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Inositol monophosphatase 1 
Protein Synonyms/Alias
  
Gene Name
 IMPA1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
36NEMNVMLKSSPVDLVubiquitination[1]
49LVTATDQKVEKMLISacetylation[2]
49LVTATDQKVEKMLISubiquitination[1]
52ATDQKVEKMLISSIKubiquitination[1, 3, 4]
59KMLISSIKEKYPSHRubiquitination[1]
110GAFCNGQKLQVSQQEubiquitination[4]
121SQQEDITKSLLVTELubiquitination[1, 4, 5]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 153 AA 
Protein Sequence
MADPWQECMD YAVTLARQAG EVVCEAIKNE MNVMLKSSPV DLVTATDQKV EKMLISSIKE 60
KYPSHRFPFV AVSIGFAVNK KIEFGVVYSC VEGKMYTARK GKGAFCNGQK LQVSQQEDIT 120
KSLLVTELGS SRTPETVRMV LSNMEKLFCI PVH 153 
Gene Ontology
 GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro. 
Interpro
 IPR000760; Inositol_monophosphatase. 
Pfam
 PF00459; Inositol_P 
SMART
  
PROSITE
  
PRINTS
 PR00377; IMPHPHTASES.