UniProt Accession

 MAFB_HUMAN; Q9Y5Q3; B3KNE1; Q9H1F1 

Genbank Protein ID

 AF134157; AK027324; AL035665; CH471077; BC028098; BC036689 

Genbank Nucleotide ID

 AAD30106.1; BAG51303.1; CAB75863.1; EAW76000.1; AAH28098.1; AAH36689.1 

Protein Name

 Transcription factor MafB 

Protein Synonyms/Alias

 Maf-B; V-maf musculoaponeurotic fibrosarcoma oncogene homolog B 

Gene Name

 MAFB 

Gene Synonyms/Alias

 KRML 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
32	DLLKFDVKKEPLGRA	sumoylation	[1, 2]
297	ERDAYKVKCEKLANS	sumoylation	[1]

Reference

 [1] SUMO modification regulates MafB-driven macrophage differentiation by enabling Myb-dependent transcriptional repression.
 Tillmanns S, Otto C, Jaffray E, Du Roure C, Bakri Y, Vanhille L, Sarrazin S, Hay RT, Sieweke MH.
 Mol Cell Biol. 2007 Aug;27(15):5554-64. [PMID: 17548468]
 [2] SUMOylation negatively regulates transcriptional and oncogenic activities of MafA.
 Kanai K, Reza HM, Kamitani A, Hamazaki Y, Han SI, Yasuda K, Kataoka K.
 Genes Cells. 2010 Sep 1;15(9):971-82. [PMID: 20718938] 

Functional Description

 Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity). Involved either as an oncogene or as a tumor suppressor, depending on the cell context. 

Sequence Annotation

 DOMAIN 238 301 bZIP.
 REGION 238 263 Basic motif (By similarity).
 REGION 266 287 Leucine-zipper (By similarity).
 CROSSLNK 32 32 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 297 297 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Activator; Complete proteome; Disease mutation; DNA-binding; Isopeptide bond; Nucleus; Proto-oncogene; Reference proteome; Repressor; Transcription; Transcription regulation; Tumor suppressor; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 323 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; TAS:ProtInc.
 GO:0005667; C:transcription factor complex; IEA:Compara.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0008134; F:transcription factor binding; IDA:UniProtKB.
 GO:0035284; P:brain segmentation; IEA:Compara.
 GO:0042472; P:inner ear morphogenesis; IEA:Compara.
 GO:0045647; P:negative regulation of erythrocyte differentiation; IDA:UniProtKB.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0007585; P:respiratory gaseous exchange; IEA:Compara.
 GO:0021571; P:rhombomere 5 development; IEA:Compara.
 GO:0021572; P:rhombomere 6 development; IEA:Compara.
 GO:0007379; P:segment specification; IEA:Compara.
 GO:0007423; P:sensory organ development; TAS:ProtInc.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR004827; bZIP.
 IPR004826; bZIP_Maf.
 IPR008917; Euk_TF_DNA-bd.
 IPR013592; Maf_TF_N.
 IPR024874; Transciption_factor_Maf. 

Pfam

 PF03131; bZIP_Maf
 PF08383; Maf_N 

SMART

 SM00338; BRLZ 

PROSITE

 PS50217; BZIP
 PS00036; BZIP_BASIC 

PRINTS