UniProt Accession

 T53I2_MOUSE; Q8CFU8; Q3TDL6; Q711P5; Q8CHM4 

Genbank Protein ID

 AJ297793; AJ311669; AL845325; AK146589; AK170132; BC036958; BC043086 

Genbank Nucleotide ID

 CAC82594.1; CAC84145.1; CAM21116.1; BAE27284.1; BAE41585.1; AAH36958.2; AAH43086.1 

Protein Name

 Tumor protein p53-inducible nuclear protein 2 

Protein Synonyms/Alias

 Diabetes and obesity-regulated protein 

Gene Name

 Tp53inp2 

Gene Synonyms/Alias

 Dor; Trp53inp2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
166	ARAVLLEKAGQVRRL	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA. 

Sequence Annotation

 MOTIF 26 41 LIR.  

Keyword

 Activator; Alternative splicing; Autophagy; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 221 AA 

Protein Sequence

Gene Ontology

 GO:0005776; C:autophagic vacuole; ISS:UniProtKB.
 GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
 GO:0000045; P:autophagic vacuole assembly; ISS:UniProtKB.
 GO:0001649; P:osteoblast differentiation; IMP:MGI.
 GO:0010508; P:positive regulation of autophagy; ISS:UniProtKB.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

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