CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002322
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cytochrome c heme lyase 
Protein Synonyms/Alias
 CCHL; Holocytochrome-c synthase 
Gene Name
 CYC3 
Gene Synonyms/Alias
 YAL039C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
70ASKQPGQKMDLPVDRubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, VillĂ©n J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301
Functional Description
 Links covalently the heme group to the apoprotein of cytochrome c. 
Sequence Annotation
 REPEAT 25 30 HRM 1.
 REPEAT 41 46 HRM 2.  
Keyword
 Complete proteome; Heme; Iron; Lyase; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 269 AA 
Protein Sequence
MGWFWADQKT TGKDIGGAAV SSMSGCPVMH ESSSSSPPSS ECPVMQGDND RINPLNNMPE 60
LAASKQPGQK MDLPVDRTIS SIPKSPDSNE FWEYPSPQQM YNAMVRKGKI GGSGEVAEDA 120
VESMVQVHNF LNEGCWQEVL EWEKPHTDES HVQPKLLKFM GKPGVLSPRA RWMHLCGLLF 180
PSHFSQELPF DRHDWIVLRG ERKAEQQPPT FKEVRYVLDF YGGPDDENGM PTFHVDVRPA 240
LDSLDNAKDR MTRFLDRMIS GPSSSSSAP 269 
Gene Ontology
 GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
 GO:0005758; C:mitochondrial intermembrane space; IDA:SGD.
 GO:0004408; F:holocytochrome-c synthase activity; IDA:SGD.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0018063; P:cytochrome c-heme linkage; IDA:SGD. 
Interpro
 IPR000511; Cyt_C/C1_haem_lyase. 
Pfam
 PF01265; Cyto_heme_lyase 
SMART
  
PROSITE
 PS00821; CYTO_HEME_LYASE_1
 PS00822; CYTO_HEME_LYASE_2 
PRINTS