CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002029
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Methyl-accepting chemotaxis protein I 
Protein Synonyms/Alias
 MCP-I; Serine chemoreceptor protein 
Gene Name
 tsr 
Gene Synonyms/Alias
 cheD; b4355; JW4318 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
239IAGGDLVKPIEVDGSacetylation[1]
Reference
 [1] The diversity of lysine-acetylated proteins in Escherichia coli.
 Yu BJ, Kim JA, Moon JH, Ryu SE, Pan JG.
 J Microbiol Biotechnol. 2008 Sep;18(9):1529-36. [PMID: 18852508
Functional Description
 Receptor for the attractant L-serine and related amino acids. Is also responsible for chemotaxis away from a wide range of repellents, including leucine, indole, and weak acids. 
Sequence Annotation
 DOMAIN 216 268 HAMP.
 DOMAIN 273 502 Methyl-accepting transducer.
 REGION 64 73 The 3 Arg may form a positively charged
 MOD_RES 297 297 Glutamate methyl ester (Gln).
 MOD_RES 304 304 Glutamate methyl ester (Glu).
 MOD_RES 311 311 Glutamate methyl ester (Gln).
 MOD_RES 493 493 Glutamate methyl ester (Glu).
 MOD_RES 502 502 Glutamate methyl ester (Glu).  
Keyword
 3D-structure; Cell inner membrane; Cell membrane; Chemotaxis; Complete proteome; Direct protein sequencing; Membrane; Methylation; Reference proteome; Transducer; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 551 AA 
Protein Sequence
MLKRIKIVTS LLLVLAVFGL LQLTSGGLFF NALKNDKENF TVLQTIRQQQ STLNGSWVAL 60
LQTRNTLNRA GIRYMMDQNN IGSGSTVAEL MESASISLKQ AEKNWADYEA LPRDPRQSTA 120
AAAEIKRNYD IYHNALAELI QLLGAGKINE FFDQPTQGYQ DGFEKQYVAY MEQNDRLHDI 180
AVSDNNASYS QAMWILVGVM IVVLAVIFAV WFGIKASLVA PMNRLIDSIR HIAGGDLVKP 240
IEVDGSNEMG QLAESLRHMQ GELMRTVGDV RNGANAIYSG ASEIATGNND LSSRTEQQAA 300
SLEETAASME QLTATVKQNA ENARQASHLA LSASETAQRG GKVVDNVVQT MRDISTSSQK 360
IADIISVIDG IAFQTNILAL NAAVEAARAG EQGRGFAVVA GEVRNLAQRS AQAAREIKSL 420
IEDSVGKVDV GSTLVESAGE TMAEIVSAVT RVTDIMGEIA SASDEQSRGI DQVGLAVAEM 480
DRVTQQNAAL VEESAAAAAA LEEQASRLTE AVAVFRIQQQ QRETSAVVKT VTPAAPRKMA 540
VADSEENWET F 551 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
 GO:0006935; P:chemotaxis; IEA:UniProtKB-KW. 
Interpro
 IPR004090; Chemotax_Me-accpt_rcpt.
 IPR003122; Chemotax_Me-accpt_rcpt_lig-bd.
 IPR004091; Chemotax_Me-accpt_rcpt_Me-site.
 IPR003660; HAMP_linker_domain.
 IPR004089; MCPsignal_dom. 
Pfam
 PF00672; HAMP
 PF00015; MCPsignal
 PF02203; TarH 
SMART
 SM00304; HAMP
 SM00283; MA
 SM00319; TarH 
PROSITE
 PS00538; CHEMOTAXIS_TRANSDUC_1
 PS50111; CHEMOTAXIS_TRANSDUC_2
 PS50885; HAMP 
PRINTS
 PR00260; CHEMTRNSDUCR.