UniProt Accession

 BCCIP_MOUSE; Q9CWI3; Q9D1E0 

Genbank Protein ID

 AK003666; AK010684; BC048465 

Genbank Nucleotide ID

 BAB22925.1; BAB27116.1; AAH48465.1 

Protein Name

 BRCA2 and CDKN1A-interacting protein 

Protein Synonyms/Alias

  

Gene Name

 Bccip 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
176	KLLNDTSKPVGLLLS	acetylation	[1, 2]
233	KTFMEAGKSSSRKRQ	ubiquitination	[3]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ) (By similarity). 

Sequence Annotation

 REGION 61 169 Interaction with BRCA2 (By similarity).
 REGION 163 261 Interaction with CDKN1A (By similarity).
 MOD_RES 44 44 Phosphoserine (By similarity).
 MOD_RES 117 117 Phosphoserine (By similarity).  

Keyword

 Cell cycle; Complete proteome; DNA damage; DNA repair; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 316 AA 

Protein Sequence

Gene Ontology

 GO:0019908; C:nuclear cyclin-dependent protein kinase holoenzyme complex; IEA:Compara.
 GO:0019207; F:kinase regulator activity; IEA:Compara.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
 GO:0061101; P:neuroendocrine cell differentiation; IEA:Compara.
 GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IEA:Compara. 

Interpro

 IPR025602; BCP1_family. 

Pfam

 PF13862; BCIP 

SMART

  

PROSITE

  

PRINTS