UniProt Accession

 S10A6_MOUSE; P14069 

Genbank Protein ID

 M37761; X66449; X52278; BC003832; BC010774 

Genbank Nucleotide ID

 AAA37358.1; CAA47065.1; CAA36521.1; AAH03832.1; AAH10774.1 

Protein Name

 Protein S100-A6 

Protein Synonyms/Alias

 5B10; Calcyclin; Prolactin receptor-associated protein; S100 calcium-binding protein A6 

Gene Name

 S100a6 

Gene Synonyms/Alias

 Cacy 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
22	IFHKYSGKEGDKHTL	acetylation	[1]
26	YSGKEGDKHTLSKKE	acetylation	[1]
35	TLSKKELKELIQKEL	acetylation	[1, 2]
40	ELKELIQKELTIGSK	acetylation	[1]
47	KELTIGSKLQDAEIA	acetylation	[1, 2, 3]
47	KELTIGSKLQDAEIA	succinylation	[3]
47	KELTIGSKLQDAEIA	ubiquitination	[4]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 May function as calcium sensor and contribute to cellular calcium signaling (Potential). May function by interacting with other proteins and indirectly play a role in the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity). Interacts with FKBP4 (By similarity). 

Sequence Annotation

 DOMAIN 12 47 EF-hand 1.
 DOMAIN 48 83 EF-hand 2.
 MOD_RES 40 40 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Calcium; Cell membrane; Complete proteome; Cytoplasm; Direct protein sequencing; Membrane; Metal-binding; Nucleus; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 89 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0031234; C:extrinsic to internal side of plasma membrane; ISS:UniProtKB.
 GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0001726; C:ruffle; IEA:Compara.
 GO:0005509; F:calcium ion binding; IDA:UniProtKB.
 GO:0015075; F:ion transmembrane transporter activity; IEA:Compara.
 GO:0008270; F:zinc ion binding; IDA:UniProtKB. 

Interpro

 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom.
 IPR001751; S100/CaBP-9k_CS.
 IPR013787; S100_Ca-bd_sub. 

Pfam

 PF01023; S_100 

SMART

  

PROSITE

 PS00018; EF_HAND_1
 PS50222; EF_HAND_2
 PS00303; S100_CABP 

PRINTS