UniProt Accession

 2AAB_HUMAN; P30154; A8MY67; B0YJ69; B4DGQ6; B4DK91; B4DWW5; F8W8G1; O75620; Q8NHV8 

Genbank Protein ID

 AF083439; AF083425; AF083426; AF083427; AF083428; AF083429; AF083430; AF083431; AF083432; AF083433; AF083434; AF083435; AF083436; AF083437; AF083438; AF087438; AF163473; AK294716; AK296455; AK301705; EF445011; EF445011; AP000925; AP001781; CH471065; CH471065; BC027596; M65254 

Genbank Nucleotide ID

 AAC63525.1; AAC63525.1; AAC63525.1; AAC63525.1; AAC63525.1; AAC63525.1; AAC63525.1; AAC63525.1; AAC63525.1; AAC63525.1; AAC63525.1; AAC63525.1; AAC63525.1; AAC63525.1; AAC63525.1; AAC69624.1; AAG39644.1; BAG57867.1; BAG59103.1; BAG63177.1; ACA06046.1; ACA06047.1; EAW67150.1; EAW67151.1; AAH27596.1; AAA59983.1 

Protein Name

 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 

Protein Synonyms/Alias

 PP2A subunit A isoform PR65-beta; PP2A subunit A isoform R1-beta 

Gene Name

 PPP2R1B 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
46	LRLNSIKKLSTIALA	ubiquitination	[1]
119	EETVVRDKAVESLRQ	ubiquitination	[1]
145	AYFVPLVKRLASGDW	ubiquitination	[1, 2, 3]
175	PRASNAVKAEIRQQF	ubiquitination	[1, 2]
200	VRRAAASKLGEFAKV	ubiquitination	[1]
206	SKLGEFAKVLELDSV	ubiquitination	[1, 2, 3]
214	VLELDSVKSEIVPLF	ubiquitination	[2, 3]
284	DRFSELQKAMGPKIT	ubiquitination	[1, 2]
289	LQKAMGPKITLNDLI	ubiquitination	[2]
304	PAFQNLLKDCEAEVR	ubiquitination	[2]
319	AAAAHKVKELGENLP	ubiquitination	[2]
386	PLFLAQLKDECPDVR	ubiquitination	[2]
484	NLMKLVQKFGTEWAQ	ubiquitination	[1, 2, 4]
497	AQNTIVPKVLVMAND	ubiquitination	[2]
539	QMLPIVLKMAGDQVA	ubiquitination	[2]
554	NVRFNVAKSLQKIGP	ubiquitination	[1]
558	NVAKSLQKIGPILDT	ubiquitination	[1, 2, 3]
573	NALQGEVKPVLQKLG	ubiquitination	[2]
578	EVKPVLQKLGQDEDM	ubiquitination	[2]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. 

Sequence Annotation

 REPEAT 20 58 HEAT 1.
 REPEAT 59 96 HEAT 2.
 REPEAT 97 135 HEAT 3.
 REPEAT 136 173 HEAT 4.
 REPEAT 174 212 HEAT 5.
 REPEAT 213 251 HEAT 6.
 REPEAT 252 290 HEAT 7.
 REPEAT 291 333 HEAT 8.
 REPEAT 334 372 HEAT 9.
 REPEAT 373 411 HEAT 10.
 REPEAT 412 450 HEAT 11.
 REPEAT 451 489 HEAT 12.
 REPEAT 490 528 HEAT 13.
 REPEAT 529 567 HEAT 14.
 REPEAT 568 601 HEAT 15.  

Keyword

 Alternative splicing; Complete proteome; Polymorphism; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 601 AA 

Protein Sequence

Gene Ontology

 GO:2001241; P:positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; IMP:UniProtKB. 

Interpro

 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR000357; HEAT.
 IPR021133; HEAT_type_2. 

Pfam

 PF02985; HEAT 

SMART

  

PROSITE

 PS50077; HEAT_REPEAT 

PRINTS