UniProt Accession

 D3Z124_MOUSE; D3Z124 

Genbank Protein ID

 AC027184 

Genbank Nucleotide ID

  

Protein Name

 DNA-(apurinic or apyrimidinic site) lyase 

Protein Synonyms/Alias

  

Gene Name

 Apex1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
34	GAAKKTEKEAAGEGP	acetylation	[1]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 177 AA 

Protein Sequence

Gene Ontology

 GO:0005813; C:centrosome; IEA:Compara.
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0016607; C:nuclear speck; IEA:Compara.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0005667; C:transcription factor complex; IEA:Compara.
 GO:0031490; F:chromatin DNA binding; IEA:Compara.
 GO:0003684; F:damaged DNA binding; IEA:Compara.
 GO:0003906; F:DNA-(apurinic or apyrimidinic site) lyase activity; IEA:Compara.
 GO:0004521; F:endoribonuclease activity; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:Compara.
 GO:0016491; F:oxidoreductase activity; IEA:Compara.
 GO:0008081; F:phosphoric diester hydrolase activity; IEA:Compara.
 GO:0016890; F:site-specific endodeoxyribonuclease activity, specific for altered base; IEA:Compara.
 GO:0003713; F:transcription coactivator activity; IEA:Compara.
 GO:0007568; P:aging; IEA:Compara.
 GO:0045454; P:cell redox homeostasis; IDA:MGI.
 GO:0071320; P:cellular response to cAMP; IEA:Compara.
 GO:0070301; P:cellular response to hydrogen peroxide; IEA:Compara.
 GO:0071375; P:cellular response to peptide hormone stimulus; IEA:Compara.
 GO:0080111; P:DNA demethylation; IEA:Compara.
 GO:0006281; P:DNA repair; IEA:InterPro.
 GO:0014912; P:negative regulation of smooth muscle cell migration; IEA:Compara.
 GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:GOC.
 GO:0045739; P:positive regulation of DNA repair; IEA:Compara.
 GO:0043488; P:regulation of mRNA stability; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara. 

Interpro

 IPR020847; AP_endonuclease_F1_BS.
 IPR005135; Endo/exonuclease/phosphatase.
 IPR004808; ExoDNase_III. 

Pfam

 PF03372; Exo_endo_phos 

SMART

  

PROSITE

 PS00726; AP_NUCLEASE_F1_1
 PS51435; AP_NUCLEASE_F1_4 

PRINTS