UniProt Accession

 FRMD8_HUMAN; Q9BZ67; Q86V56; Q8NCB5 

Genbank Protein ID

 AF334946; AK074850; BC044658; BC051695 

Genbank Nucleotide ID

 AAG50295.1; BAC11244.1; AAH44658.1; AAH51695.1 

Protein Name

 FERM domain-containing protein 8 

Protein Synonyms/Alias

  

Gene Name

 FRMD8 

Gene Synonyms/Alias

 FKSG44 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
133	RRNVFFPKRRELQIH	ubiquitination	[1]
153	RLLYEEAKGNVLAAR	ubiquitination	[1, 2, 3]
196	AACDLREKLDSFLPA	ubiquitination	[1]
207	FLPAHLCKRGQSLFA	ubiquitination	[1]
260	HYRAYLLKCHELPFY	ubiquitination	[1]
309	HVIDSREKHVLLGLR	ubiquitination	[1]
349	SEGTPVNKLLKIYSK	ubiquitination	[2]
352	TPVNKLLKIYSKQAE	ubiquitination	[1]
427	IDYVEDGKGIRRVKP	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

  

Sequence Annotation

 DOMAIN 30 376 FERM.
 MOD_RES 20 20 Phosphoserine (By similarity).
 MOD_RES 21 21 Phosphoserine (By similarity).
 MOD_RES 419 419 Phosphothreonine (By similarity).
 MOD_RES 439 439 Phosphoserine.
 MOD_RES 446 446 Phosphoserine.  

Keyword

 Alternative splicing; Complete proteome; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 464 AA 

Protein Sequence

Gene Ontology

 GO:0005856; C:cytoskeleton; IEA:InterPro. 

Interpro

 IPR019749; Band_41_domain.
 IPR014352; FERM/acyl-CoA-bd_prot_3-hlx.
 IPR019748; FERM_central.
 IPR000299; FERM_domain. 

Pfam

 PF00373; FERM_M 

SMART

 SM00295; B41 

PROSITE

 PS00660; FERM_1
 PS00661; FERM_2
 PS50057; FERM_3 

PRINTS