UniProt Accession

 ARPC5_HUMAN; O15511; A6NEC4; Q6PG42 

Genbank Protein ID

 AF006088; AF017807; AL137800; AL137800; CH471067; BC057237 

Genbank Nucleotide ID

 AAB64193.1; AAB70561.1; CAC19687.1; CAI19482.1; EAW91163.1; AAH57237.1 

Protein Name

 Actin-related protein 2/3 complex subunit 5 

Protein Synonyms/Alias

 Arp2/3 complex 16 kDa subunit; p16-ARC 

Gene Name

 ARPC5 

Gene Synonyms/Alias

 ARC16 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
70	KNPPINTKSQAVKDR	ubiquitination	[1]
111	NGVDLLMKYIYKGFE	ubiquitination	[1]
115	LLMKYIYKGFESPSD	ubiquitination	[2]
134	MLLQWHEKALAAGGV	ubiquitination	[2]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. 

Sequence Annotation

  

Keyword

 Actin-binding; Alternative splicing; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 151 AA 

Protein Sequence

Gene Ontology

 GO:0005885; C:Arp2/3 protein complex; TAS:ProtInc.
 GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005200; F:structural constituent of cytoskeleton; TAS:ProtInc.
 GO:0030036; P:actin cytoskeleton organization; TAS:ProtInc.
 GO:0006928; P:cellular component movement; TAS:ProtInc.
 GO:0038096; P:Fc-gamma receptor signaling pathway involved in phagocytosis; TAS:Reactome.
 GO:0045087; P:innate immune response; TAS:Reactome.
 GO:0030833; P:regulation of actin filament polymerization; IEA:InterPro. 

Interpro

 IPR006789; ARP2/3_p16_Arc. 

Pfam

 PF04699; P16-Arc 

SMART

  

PROSITE

  

PRINTS