CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001716
UniProt Accession
Genbank Protein ID
 U94177 
Genbank Nucleotide ID
Protein Name
 Androgen receptor 
Protein Synonyms/Alias
 Dihydrotestosterone receptor; Nuclear receptor subfamily 3 group C member 4 
Gene Name
 AR 
Gene Synonyms/Alias
 NR3C4 
Created Date
 July 27, 2013 
Organism
 Pan troglodytes (Chimpanzee) 
NCBI Taxa ID
 9598 
Lysine Modification
Position
Peptide
Type
References
712VHVVKWAKALPGFRNubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2.Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 (By similarity). 
Sequence Annotation
 DNA_BIND 551 623 Nuclear receptor.
 ZN_FING 551 571 NR C4-type.
 ZN_FING 587 611 NR C4-type.
 REGION 1 549 Modulating (By similarity).
 REGION 543 911 Interaction with LPXN (By similarity).
 REGION 563 653 Interaction with HIPK3 (By similarity).
 REGION 616 911 Interaction with KAT7 (By similarity).
 REGION 682 911 Ligand-binding.
 BINDING 697 697 Androgen.
 BINDING 744 744 Androgen.
 BINDING 869 869 Androgen.
 MOD_RES 81 81 Phosphoserine; by CDK9 (By similarity).
 MOD_RES 93 93 Phosphoserine (By similarity).
 MOD_RES 222 222 Phosphotyrosine; by CSK (By similarity).
 MOD_RES 266 266 Phosphotyrosine; by CSK and TNK2 (By
 MOD_RES 306 306 Phosphotyrosine; by CSK (By similarity).
 MOD_RES 345 345 Phosphotyrosine; by CSK (By similarity).
 MOD_RES 356 356 Phosphotyrosine; by CSK (By similarity).
 MOD_RES 361 361 Phosphotyrosine; by CSK (By similarity).
 MOD_RES 362 362 Phosphotyrosine; by CSK and TNK2 (By
 MOD_RES 392 392 Phosphotyrosine; by CSK (By similarity).
 MOD_RES 526 526 Phosphotyrosine; by CSK (By similarity).
 MOD_RES 543 543 Phosphotyrosine; by CSK (By similarity).
 MOD_RES 642 642 Phosphoserine; by STK4/MST1 (By
 MOD_RES 907 907 Phosphotyrosine; by CSK (By similarity).
 CROSSLNK 385 385 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 512 512 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 837 837 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 839 839 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 3D-structure; Complete proteome; Cytoplasm; DNA-binding; Isopeptide bond; Lipid-binding; Lipoprotein; Metal-binding; Nucleus; Palmitate; Phosphoprotein; Receptor; Reference proteome; Steroid-binding; Transcription; Transcription regulation; Ubl conjugation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 911 AA 
Protein Sequence
MEVQLGLGRV YPRPPSKTYR GAFQNLFQSV REVIQNPGPR HPEAASAAPP GASLLLQQQQ 60
QQQQQQQQQQ QQQQQQQQET SPRQQQQQGE DGSPQAHRRG PTGYLVLDEE QQPSQPQSAP 120
ECHPERGCVP EPGAAVAASK GLPQQLPAPP DEDDSAAPST LSLLGPTFPG LSSCSADLKD 180
ILSEASTMQL LQQQQQEAVS EGSSSGRARE ASGAPTSSKD NYLGGTSTIS DSAKELCKAV 240
SVSMGLGVEA LEHLSPGEQL RGDCMYAPLL GVPPAVRPTP CAPLAECKGS LLDDSAGKST 300
EDTAEYSPFK GGYTKGLEGE SLGCSGSAAA GSSGTLELPS TLSLYKSGAL DEAAAYQSRD 360
YYNFPLALAG PPPPPPPPHP HARIKLENPL DYGSAWAAAA AQCRYGDLAS LHGAGAAGPG 420
SGSPSAAASS SWHTLFTAEE GQLYGPCGGG GGGGGGGGGG GGGGEAGAVA PYGYTRPPQG 480
LAGQEGDFTA PDVWYPGGMV SRVPYPSPTC VKSEMGPWMD SYSGPYGDMR LETARDHVLP 540
IDYYFPPQKT CLICGDEASG CHYGALTCGS CKVFFKRAAE GKQKYLCASR NDCTIDKFRR 600
KNCPSCRLRK CYEAGMTLGA RKLKKLGNLK LQEEGEASST TSPTEETTQK LTVSHIEGYE 660
CQPIFLNVLE AIEPGVVCAG HDNNQPDSFA ALLSSLNELG ERQLVHVVKW AKALPGFRNL 720
HVDDQMAVIQ YSWMGLMVFA MGWRSFTNVN SRMLYFAPDL VFNEYRMHKS RMYSQCVRMR 780
HLSQEFGWLQ ITPQEFLCMK ALLLFSIIPV DGLKNQKFFD ELRMNYIKEL DRIIACKRKN 840
PTSCSRRFYQ LTKLLDSVQP IARELHQFTF DLLIKSHMVS VDFPEMMAEI ISVQVPKILS 900
GKVKPIYFHT Q 911 
Gene Ontology
 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0000790; C:nuclear chromatin; ISS:UniProtKB.
 GO:0004882; F:androgen receptor activity; ISS:UniProtKB.
 GO:0008013; F:beta-catenin binding; ISS:UniProtKB.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0005496; F:steroid binding; IEA:UniProtKB-KW.
 GO:0044212; F:transcription regulatory region DNA binding; ISS:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
 GO:0045720; P:negative regulation of integrin biosynthetic process; ISS:UniProtKB.
 GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB.
 GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.
 GO:0042327; P:positive regulation of phosphorylation; ISS:UniProtKB.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
 GO:0090003; P:regulation of establishment of protein localization to plasma membrane; ISS:UniProtKB. 
Interpro
 IPR001103; Andrgn_rcpt.
 IPR008946; Nucl_hormone_rcpt_ligand-bd.
 IPR000536; Nucl_hrmn_rcpt_lig-bd_core.
 IPR001628; Znf_hrmn_rcpt.
 IPR013088; Znf_NHR/GATA. 
Pfam
 PF02166; Androgen_recep
 PF00104; Hormone_recep
 PF00105; zf-C4 
SMART
 SM00430; HOLI
 SM00399; ZnF_C4 
PROSITE
 PS00031; NUCLEAR_REC_DBD_1
 PS51030; NUCLEAR_REC_DBD_2 
PRINTS
 PR00521; ANDROGENR.
 PR00047; STROIDFINGER.