| Tag | Content |
|---|
| CPLM ID | CPLM-011438 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein CFT1 |
Protein Synonyms/Alias | Cleavage factor two protein 1 |
Gene Name | CFT1 |
Gene Synonyms/Alias | YHH1; YDR301W |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 942 | SNVLDDYKTLQKLVY | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Involved in poly(A) site recognition. May be involved in coupling transcription termination and mRNA 3'-end formation. |
Sequence Annotation | |
Keyword | Complete proteome; mRNA processing; Nucleus; Reference proteome; RNA-binding. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1357 AA |
Protein Sequence | MNVYDDVLDA TVVSHSLATH FTTSDYEELL VVRTNILSVY RPTRDGKLYL TDEFKFHGLI 60
TDIGLIPQKD SPLSCLLLCT GVAKISILKF NTLTNSIDTL SLHYYEGKFK GKSLVELAKI 120
STLRMDPGSS CALLFNNDII AFLPFHVNKN DDDEEEEDED ENIDDSELIH SMNQKSQGTN 180
TFNKRKRTKL GDKFTAPSVV LVASELYEGA KNIIDIQFLK NFTKPTIALL YQPKLVWAGN 240
TTISKLPTQY VILTLNIQPA ESATKIESTT IAFVKELPWD LHTIVPVSNG AIIVGTNELA 300
FLDNTGVLQS TVLLNSFADK ELQKTKIINN SSLEIMFREK NTTSIWIPSS KSKNGGSNND 360
ETLLLMDLKS NIYYIQMEAE GRLLIKFDIF KLPIVNDLLK ENSNPKCITR LNATNSNKNM 420
DLFIGFGSGN ALVLRLNNLK STIETREAHN PSSGTNSLMD INDDDDEEMD DLYADEAPEN 480
GLTTNDSKGT VETVQPFDIE LLSSLRNVGP ITSLTVGKVS SIDDVVKGLP NPNKNEYSLV 540
ATSGNGSGSH LTVIQTSVQP EIELALKFIS ITQIWNLKIK GRDRYLITTD STKSRSDIYE 600
SDNNFKLHKG GRLRRDATTV YISMFGEEKR IIQVTTNHLY LYDTHFRRLT TIKFDYEVIH 660
VSVMDPYILV TVSRGDIKIF ELEEKNKRKL LKVDLPEILN EMVITSGLIL KSNMCNEFLI 720
GLSKSQEEQL LFTFVTADNQ IIFFTKDHND RIFQLNGVDQ LNESLYISTY QLGDEIVPDP 780
SIKQVMINKL GHDNKEEYLT ILTFGGEIYQ YRKLPQRRSR FYRNVTRNDL AITGAPDNAY 840
AKGVSSIERI MHYFPDYNGY SVIFVTGSVP YILIKEDDST PKIFKFGNIP LVSVTPWSER 900
SVMCVDDIKN ARVYTLTTDN MYYGNKLPLK QIKISNVLDD YKTLQKLVYH ERAQLFLVSY 960
CKRVPYEALG EDGEKVIGYD ENVPHAEGFQ SGILLINPKS WKVIDKIDFP KNSVVNEMRS 1020
SMIQINSKTK RKREYIIAGV ANATTEDTPP TGAFHIYDVI EVVPEPGKPD TNYKLKEIFQ 1080
EEVSGTVSTV CEVSGRFMIS QSQKVLVRDI QEDNSVIPVA FLDIPVFVTD SKSFGNLLII 1140
GDAMQGFQFI GFDAEPYRMI SLGRSMSKFQ TMSLEFLVNG GDMYFAATDA DRNVHVLKYA 1200
PDEPNSLSGQ RLVHCSSFTL HSTNSCMMLL PRNEEFGSPQ VPSFQNVGGQ VDGSVFKIVP 1260
LSEEKYRRLY VIQQQIIDRE LQLGGLNPRM ERLANDFYQM GHSMRPMLDF NVIRRFCGLA 1320
IDRRKSIAQK AGRHAHFEAW RDIINIEFSM RSLCQGK 1357 |
Gene Ontology | GO:0005739; C:mitochondrion; IDA:SGD. GO:0005847; C:mRNA cleavage and polyadenylation specificity factor complex; IDA:SGD. GO:0003723; F:RNA binding; IDA:SGD. GO:0006379; P:mRNA cleavage; TAS:SGD. GO:0006378; P:mRNA polyadenylation; TAS:SGD. GO:0006369; P:termination of RNA polymerase II transcription; IMP:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |