CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017490
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ER membrane protein complex subunit 1 
Protein Synonyms/Alias
  
Gene Name
 EMC1 
Gene Synonyms/Alias
 KIAA0090; PSEC0263 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
52LEFSPGSKKLVVATEubiquitination[1]
344ACRNEVQKSSSSEDGubiquitination[1]
359SMGSFSEKSSSKDSLubiquitination[1]
619QVAPPVLKRPILQSLubiquitination[1]
733GDRSVLYKSLNPNLLubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
  
Sequence Annotation
 CARBOHYD 913 913 N-linked (GlcNAc...).  
Keyword
 Alternative splicing; Complete proteome; Glycoprotein; Membrane; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 993 AA 
Protein Sequence
MAAEWASRFW LWATLLIPAA AVYEDQVGKF DWRQQYVGKV KFASLEFSPG SKKLVVATEK 60
NVIAALNSRT GEILWRHVDK GTAEGAVDAM LLHGQDVITV SNGGRIMRSW ETNIGGLNWE 120
ITLDSGSFQA LGLVGLQESV RYIAVLKKTT LALHHLSSGH LKWVEHLPES DSIHYQMVYS 180
YGSGVVWALG VVPFSHVNIV KFNVEDGEIV QQVRVSTPWL QHLSGACGVV DEAVLVCPDP 240
SSRSLQTLAL ETEWELRQIP LQSLDLEFGS GFQPRVLPTQ PNPVDASRAQ FFLHLSPSHY 300
ALLQYHYGTL SLLKNFPQTA LVSFATTGEK TVAAVMACRN EVQKSSSSED GSMGSFSEKS 360
SSKDSLACFN QTYTINLYLV ETGRRLLDTT ITFSLEQSGT RPERLYIQVF LKKDDSVGYR 420
ALVQTEDHLL LFLQQLGKVV LWSREESLAE VVCLEMVDLP LTGAQAELEG EFGKKADGLL 480
GMFLKRLSSQ LILLQAWTSH LWKMFYDARK PRSQIKNEIN IDTLARDEFN LQKMMVMVTA 540
SGKLFGIESS SGTILWKQYL PNVKPDSSFK LMVQRTTAHF PHPPQCTLLV KDKESGMSSL 600
YVFNPIFGKW SQVAPPVLKR PILQSLLLPV MDQDYAKVLL LIDDEYKVTA FPATRNVLRQ 660
LHELAPSIFF YLVDAEQGRL CGYRLRKDLT TELSWELTIP PEVQRIVKVK GKRSSEHVHS 720
QGRVMGDRSV LYKSLNPNLL AVVTESTDAH HERTFIGIFL IDGVTGRIIH SSVQKKAKGP 780
VHIVHSENWV VYQYWNTKAR RNEFTVLELY EGTEQYNATA FSSLDRPQLP QVLQQSYIFP 840
SSISAMEATI TERGITSRHL LIGLPSGAIL SLPKALLDPR RPEIPTEQSR EENLIPYSPD 900
VQIHAERFIN YNQTVSRMRG IYTAPSGLES TCLVVAYGLD IYQTRVYPSK QFDVLKDDYD 960
YVLISSVLFG LVFATMITKR LAQVKLLNRA WR 992 
Gene Ontology
 GO:0072546; C:ER membrane protein complex; IDA:UniProtKB. 
Interpro
 IPR011678; DUF1620.
 IPR026895; EMC1.
 IPR027295; Quinonprotein_ADH-like_fam.
 IPR011047; Quinonprotein_ADH-like_supfam. 
Pfam
 PF07774; DUF1620 
SMART
  
PROSITE
  
PRINTS