CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017092
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cytoskeleton-associated protein 2-like 
Protein Synonyms/Alias
  
Gene Name
 CKAP2L 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
151IEQLKTTKQQLTDQGubiquitination[1]
198ILTEPERKPDPKLYTsumoylation[2]
257QSRTFPVKSQQLSRGubiquitination[3]
438FLNKTAPKTQADVTTubiquitination[1]
457QTNPNIKKKATAEDRubiquitination[1]
561FAKFWICKAKLLASKubiquitination[1]
582GLYEEAIKNGATPIQubiquitination[1]
593TPIQELRKVVLNILQubiquitination[1]
634AKKMESVKSCLSPKEubiquitination[1]
653TATPRIAKAEQHNYPubiquitination[1]
663QHNYPGIKLQIGPIPubiquitination[1]
682MPEVQDMKFITPVRRubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] In vivo identification of sumoylation sites by a signature tag and cysteine-targeted affinity purification.
 Blomster HA, Imanishi SY, Siimes J, Kastu J, Morrice NA, Eriksson JE, Sistonen L.
 J Biol Chem. 2010 Jun 18;285(25):19324-9. [PMID: 20388717]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
  
Sequence Annotation
 MOD_RES 204 204 Phosphotyrosine.
 MOD_RES 742 742 Phosphothreonine.
 MOD_RES 745 745 Phosphoserine.
 CROSSLNK 198 198 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Alternative splicing; Complete proteome; Isopeptide bond; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 745 AA 
Protein Sequence
MVGPGPTAAA AVEERQRKLQ EYLAAKGKLK SQNTKPYLKS KNNCQNQPPS KSTIRPKNDV 60
TNHVVLPVKP KRSISIKLQP RPPNTAGSQK PKLEPPKLLG KRLTSECVSS NPYSKPSSKS 120
FQQCEAGSST TGELSRKPVG SLNIEQLKTT KQQLTDQGNG KCIDFMNNIH VENESLDNFL 180
KETNKENLLD ILTEPERKPD PKLYTRSKPK TDSYNQTKNS LVPKQALGKS SVNSAVLKDR 240
VNKQFVGETQ SRTFPVKSQQ LSRGADLARP GVKPSRTVPS HFIRTLSKVQ SSKKPVVKNI 300
KDIKVNRSQY ERPNETKIRS YPVTEQRVKH TKPRTYPSLL QGEYNNRHPN IKQDQKSSQV 360
CIPQTSCVLQ KSKAISQRPN LTVGRFNSAI PSTPSIRPNG TSGNKHNNNG FQQKAQTLDS 420
KLKKAVPQNH FLNKTAPKTQ ADVTTVNGTQ TNPNIKKKAT AEDRRKQLEE WQKSKGKTYK 480
RPPMELKTKR KVIKEMNISF WKSIEKEEEE KKAQLELSSK INNTLTECLN LIEGGVPSNE 540
ILNILSSIPE AEKFAKFWIC KAKLLASKGT FDVIGLYEEA IKNGATPIQE LRKVVLNILQ 600
DSNRTTEGIT SDSLVAETSI TSVEELAKKM ESVKSCLSPK EREQVTATPR IAKAEQHNYP 660
GIKLQIGPIP RINGMPEVQD MKFITPVRRS SRIERAVSRY PEMLQEHDLV VASLDELLEV 720
EETKCFIFRR NEALPVTLGF QTPES 745 
Gene Ontology
 GO:0005813; C:centrosome; IDA:UniProtKB. 
Interpro
 IPR026167; CKAP2-like.
 IPR026165; CKAP2_fam. 
Pfam
  
SMART
  
PROSITE
  
PRINTS