CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031255
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 U3 small nucleolar RNA-associated protein 15 homolog 
Protein Synonyms/Alias
 cDNA FLJ61408, highly similar to U3 small nucleolar RNA-associated protein 15 homolog 
Gene Name
 UTP15 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
169LINRPAKKHLELYDRubiquitination[1, 2]
179ELYDRDLKHFRISKAubiquitination[1]
185LKHFRISKALDRVLDubiquitination[1, 2]
198LDPTCTIKTPEITVSubiquitination[2]
208EITVSIIKELNRRGVubiquitination[1, 3, 4]
282LLQGLVEKEIDYQREubiquitination[5]
307LFATMRRKEGTSVLEubiquitination[5]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 328 AA 
Protein Sequence
MFDARTSESV LSVEHGQPVE SVLLFPSGGL LVSAGGRYVK VWDMLKGGQL LVSLKNHHKT 60
VTCLCLSSSG QRLLSGSLDR KVKVYSTTSY KVVHSFDYAA SILSLALAHE DETIVVGMTN 120
GILSVKHRKS EAKKESLPRR RRPAYRTFIK GKNYMKQRDD ILINRPAKKH LELYDRDLKH 180
FRISKALDRV LDPTCTIKTP EITVSIIKEL NRRGVLANAL AGRDEKEISH VLNFLIRNLS 240
QPRFAPVLIN AAEIIIDIYL PVIGQSPVVD KKFLLLQGLV EKEIDYQREL LETLGMMDML 300
FATMRRKEGT SVLEHTSDGF PENKKIES 328 
Gene Ontology
 GO:0005730; C:nucleolus; IEA:InterPro.
 GO:0006364; P:rRNA processing; IEA:InterPro. 
Interpro
 IPR018983; U3_snoRNA-assocProt_15_C.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF09384; UTP15_C
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS