CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-045484
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Pyruvate kinase 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
267GIEIPAEKVFLAQKMacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Glycolysis; Kinase; Magnesium; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 476 AA 
Protein Sequence
QTQQLHAAMA DIFLEHMCRL DVDSPPITAC NTGIICTIGP APNMEMLKEM IKSGMNVARL 60
NFSHGTHEYH AETIKNVRAA TESFAYRPVA VALDTKGPEI RTELIKGSGT AEVELKKGAT 120
LKITLGNAYM NTLWLDCKNI CKVYVDDGLI SLQVKEKGAD YLVTEVENGD SLGSKKGVNL 180
PGAAVNFPGV SEKDIQNLKF GVEQDVDILF ASFIHKAEKV LGEKGKNIKI SKIENHEGVR 240
RFHEILEASD GIMVARGDLG IEIPAEKVFL AQKMIGRCNH AGKPVICATQ LLESMIKKPR 300
PPRAEGSDDA DSIMLSRETA KGDYPLEVVR LQHLIAREAD AAINHLQLFE ELRSRLVPIT 360
NDPTEAATVG AEASFKCCSG AIIALTKSRR SAHQVAQYHL RAPIIAETRN PQTARQAHLD 420
RAIFPVLSED VGLRVNLAMN VGKARGFFKK GDVVIVLTGW RPGSGFTNTM CVVPVP 476 
Gene Ontology
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0030955; F:potassium ion binding; IEA:InterPro.
 GO:0004743; F:pyruvate kinase activity; IEA:EC.
 GO:0006096; P:glycolysis; IEA:UniProtKB-KW. 
Interpro
 IPR001697; Pyr_Knase.
 IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
 IPR011037; Pyrv_Knase-like_insert_dom.
 IPR015794; Pyrv_Knase_a/b.
 IPR015793; Pyrv_Knase_brl.
 IPR015795; Pyrv_Knase_C.
 IPR015806; Pyrv_Knase_insert_dom. 
Pfam
 PF00224; PK
 PF02887; PK_C 
SMART
  
PROSITE
  
PRINTS
 PR01050; PYRUVTKNASE.