| Tag | Content |
|---|
| CPLM ID | CPLM-003237 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Iron-binding protein IscA |
Protein Synonyms/Alias | Iron-sulfur cluster assembly protein |
Gene Name | iscA |
Gene Synonyms/Alias | yfhF; b2528; JW2512 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 67 | VKVVVDGKSLQFLDG | acetylation | [1] | | 81 | GTQLDFVKEGLNEGF | acetylation | [1] | | 89 | EGLNEGFKFTNPNVK | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Is able to transfer iron-sulfur clusters to apo- ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB. |
Sequence Annotation | METAL 35 35 Iron (Probable).
METAL 99 99 Iron (Probable).
METAL 101 101 Iron (Probable). |
Keyword | 3D-structure; Complete proteome; Iron; Metal-binding; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 107 AA |
Protein Sequence | MSITLSDSAA ARVNTFLANR GKGFGLRLGV RTSGCSGMAY VLEFVDEPTP EDIVFEDKGV 60
KVVVDGKSLQ FLDGTQLDFV KEGLNEGFKF TNPNVKDECG CGESFHV 107 |
Gene Ontology | GO:0051537; F:2 iron, 2 sulfur cluster binding; IDA:UniProtKB. GO:0008198; F:ferrous iron binding; IDA:EcoCyc. GO:0034986; F:iron chaperone activity; IDA:EcoCyc. GO:0005198; F:structural molecule activity; IEA:InterPro. GO:0016226; P:iron-sulfur cluster assembly; IDA:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |