| Tag | Content |
|---|
| CPLM ID | CPLM-006310 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Transcription factor tau 131 kDa subunit |
Protein Synonyms/Alias | TFIIIC 131 kDa subunit; Transcription factor C subunit 4 |
Gene Name | TFC4 |
Gene Synonyms/Alias | PCF1; YGR047C |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 581 | LHRISNEKSSNDTSD | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauA domain of TFIIIC that binds boxA DNA promoter sites of tRNA and similar genes. TFC4 is the TFIIIB-assembling subunit of TFIIIC and essential for viability. |
Sequence Annotation | REPEAT 128 161 TPR 1.
REPEAT 162 195 TPR 2.
REPEAT 196 229 TPR 3.
REPEAT 230 263 TPR 4.
REPEAT 264 297 TPR 5.
REPEAT 432 465 TPR 6.
REPEAT 467 501 TPR 7.
REPEAT 502 535 TPR 8.
REPEAT 536 569 TPR 9.
REPEAT 875 908 TPR 10.
REPEAT 959 992 TPR 11.
REGION 128 569 Sufficient to bind BDP1.
MOD_RES 311 311 Phosphoserine. |
Keyword | Complete proteome; Direct protein sequencing; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; TPR repeat; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1025 AA |
Protein Sequence | MAAGKLKKEQ QNQSAERESA DTGKVNDEDE EHLYGNIDDY KHLIQDEEYD DEDVPHDLQL 60
SEDEYNSERD SSLLAEFSDY GEISEDDEED FMNAIREASN FKVKKKKKND KGKSYGRQRK 120
ERVLDPEVAQ LLSQANEAFV RNDLQVAERL FNEVIKKDAR NFAAYETLGD IYQLQGRLND 180
CCNSWFLAAH LNASDWEFWK IVAILSADLD HVRQAIYCFS RVISLNPMEW ESIYRRSMLY 240
KKTGQLARAL DGFQRLYMYN PYDANILREL AILYVDYDRI EDSIELYMKV FNANVERREA 300
ILAALENALD SSDEESAAEG EDADEKEPLE QDEDRQMFPD INWKKIDAKY KCIPFDWSSL 360
NILAELFLKL AVSEVDGIKT IKKCARWIQR RESQTFWDHV PDDSEFDNRR FKNSTFDSLL 420
AAEKEKSYNI PIDIRVRLGL LRLNTDNLVE ALNHFQCLYD ETFSDVADLY FEAATALTRA 480
EKYKEAIDFF TPLLSLEEWR TTDVFKPLAR CYKEIESYET AKEFYELAIK SEPDDLDIRV 540
SLAEVYYRLN DPETFKHMLV DVVEMRKHQV DETLHRISNE KSSNDTSDIS SKPLLEDSKF 600
RTFRKKKRTP YDAERERIER ERRITAKVVD KYEKMKKFEL NSGLNEAKQA SIWINTVSEL 660
VDIFSSVKNF FMKSRSRKFV GILRRTKKFN TELDFQIERL SKLAEGDSVF EGPLMEERVT 720
LTSATELRGL SYEQWFELFM ELSLVIAKYQ SVEDGLSVVE TAQEVNVFFQ DPERVKMMKF 780
VKLAIVLQMD DEEELAENLR GLLNQFQFNR KVLQVFMYSL CRGPSSLNIL SSTIQQKFFL 840
RQLKAFDSCR YNTEVNGQAS ITNKEVYNPN KKSSPYLYYI YAVLLYSSRG FLSALQYLTR 900
LEEDIPDDPM VNLLMGLSHI HRAMQRLTAQ RHFQIFHGLR YLYRYHKIRK SLYTDLEKQE 960
ADYNLGRAFH LIGLVSIAIE YYNRVLENYD DGKLKKHAAY NSIIIYQQSG NVELADHLME 1020
KYLSI 1025 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:SGD. GO:0000127; C:transcription factor TFIIIC complex; IDA:SGD. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0000999; P:RNA polymerase III type 1 promoter transcriptional preinitiation complex assembly; IDA:GOC. GO:0001021; P:RNA polymerase III type 2 promoter transcriptional preinitiation complex assembly; IDA:GOC. GO:0001041; P:transcription from a RNA polymerase III hybrid type promoter; IDA:SGD. |
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Pfam | |
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PRINTS | |