UniProt Accession

 EIF3F_HUMAN; O00303; A8K0S2; Q6IB45; Q8N978 

Genbank Protein ID

 U94855; AK095574; AK289637; AK291354; BT006894; CR456959; BC000490 

Genbank Nucleotide ID

 AAD03467.1; BAC04577.1; BAF82326.1; BAF84043.1; AAP35540.1; CAG33240.1; AAH00490.1 

Protein Name

 Eukaryotic translation initiation factor 3 subunit F 

Protein Synonyms/Alias

 eIF3f; Deubiquitinating enzyme eIF3f; Eukaryotic translation initiation factor 3 subunit 5; eIF-3-epsilon; eIF3 p47 

Gene Name

 EIF3F 

Gene Synonyms/Alias

 EIF3S5 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
238	MFTPLTVKYAYYDTE	acetylation	[1]
238	MFTPLTVKYAYYDTE	ubiquitination	[2]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. 

Sequence Annotation

 DOMAIN 87 196 MPN.
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 46 46 Phosphoserine; by CDK11; in vitro.
 MOD_RES 238 238 N6-acetyllysine.
 MOD_RES 258 258 Phosphoserine.  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Hydrolase; Initiation factor; Phosphoprotein; Polymorphism; Protease; Protein biosynthesis; Reference proteome; Thiol protease; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 357 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:HAMAP.
 GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:HAMAP.
 GO:0005852; C:eukaryotic translation initiation factor 3 complex; IDA:UniProtKB.
 GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
 GO:0003743; F:translation initiation factor activity; TAS:UniProtKB.
 GO:0001731; P:formation of translation preinitiation complex; IEA:HAMAP.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
 GO:0006446; P:regulation of translational initiation; IEA:HAMAP. 

Interpro

 IPR027531; eIF3f.
 IPR000555; JAB1_Mov34_MPN_PAD1.
 IPR024969; Rpn11/EIF3F_C. 

Pfam

 PF01398; JAB
 PF13012; MitMem_reg 

SMART

 SM00232; JAB_MPN 

PROSITE

  

PRINTS