| Tag | Content |
|---|
| CPLM ID | CPLM-014652 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Liver carboxylesterase 4 |
Protein Synonyms/Alias | Carboxyesterase ES-4; Kidney microsomal carboxylesterase; Microsomal palmitoyl-CoA hydrolase |
Gene Name | |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 258 | FLPGLLTKDVRPAAK | acetylation | [1] | | 288 | IVHCLRQKTEEELLE | acetylation | [1] | | 298 | EELLEIMKKMNLIKL | acetylation | [1] | | 312 | LSSQRDNKESYHFLS | acetylation | [1] | | 400 | IIPVAIEKYRKGSDD | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes omicron- nitrophenyl acetate and alpha-naphthyl acetate. It also hydrolyzes acetanilide and, distinctively, palmitoyl-CoA. |
Sequence Annotation | MOTIF 558 561 Prevents secretion from ER (Potential).
ACT_SITE 221 221 Acyl-ester intermediate (By similarity).
ACT_SITE 353 353 Charge relay system (By similarity).
ACT_SITE 466 466 Charge relay system (By similarity).
CARBOHYD 79 79 N-linked (GlcNAc...) (Potential).
DISULFID 87 116 By similarity.
DISULFID 273 284 By similarity. |
Keyword | Complete proteome; Disulfide bond; Endoplasmic reticulum; Glycoprotein; Hydrolase; Reference proteome; Serine esterase; Signal. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 561 AA |
Protein Sequence | MCLSFLFLVS LATCVVYGNP SSPPVVDTTK GKVLGKYVSL EGVTQSVAVF LGVPFAKPPL 60
GSLRFAPPQP AEPWSFVKNT TTYPPMCSQD AAKGQRMNDL LTNRKEKIHL EFSEDCLYLN 120
IYTPADFTKN SRLPVMVWIH GGGMTLGGAS TYDGRVLSAY ENVVVVAIQY RLGIWGFFST 180
GDEHSRGNWG HLDQVAALHW VQDNIANFGG DPGSVTIFGE SAGGFSVSVL VLSPLTKNLF 240
HRAISESGVV FLPGLLTKDV RPAAKQIADM AGCETTTSAI IVHCLRQKTE EELLEIMKKM 300
NLIKLSSQRD NKESYHFLST VVDNVVLPKD PKEILAEKNF NTVPYIVGIN KQECGWLLPT 360
MMGFVPADVE LDKKMAITLL EKFASLYGIP EDIIPVAIEK YRKGSDDSIK IRDGILAFIG 420
DVSFSIPSVM VSRDHRDAGA PTYMYEYQYY PSFSSPQRPK HVVGDHADDL YSVFGAPILR 480
DGASEEEIKL SKMVMKFWAN FARNGNPNGR GLPHWPQYDQ KEEYLQIGAT TQQSQRLKAE 540
EVAFWTQLLA KRQPQPHHNE L 561 |
Gene Ontology | GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell. GO:0004091; F:carboxylesterase activity; IBA:RefGenome. GO:0080030; F:methyl indole-3-acetate esterase activity; IEA:EC. GO:0080032; F:methyl jasmonate esterase activity; IEA:EC. GO:0080031; F:methyl salicylate esterase activity; IEA:EC. GO:0050253; F:retinyl-palmitate esterase activity; IEA:EC. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |