| Tag | Content |
|---|
| CPLM ID | CPLM-004711 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Guanine nucleotide-binding protein subunit beta |
Protein Synonyms/Alias | |
Gene Name | STE4 |
Gene Synonyms/Alias | YOR212W; YOR50-2 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 59 | QINKAKHKIQDASLF | ubiquitination | [1] | | 71 | SLFQMANKVTSLTKN | ubiquitination | [1, 2] | | 77 | NKVTSLTKNKINLKP | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] [2] Sites of ubiquitin attachment in Saccharomyces cerevisiae. Starita LM, Lo RS, Eng JK, von Haller PD, Fields S. Proteomics. 2012 Jan;12(2):236-40. [ PMID: 22106047] |
Functional Description | Implicated in the a- and alpha-factor response pathway. The beta and gamma chains of the putative yeast mating response pathway G protein play a positive role in initiation of the mating response. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction. |
Sequence Annotation | REPEAT 90 120 WD 1.
REPEAT 132 162 WD 2.
REPEAT 179 208 WD 3.
REPEAT 220 256 WD 4.
REPEAT 268 298 WD 5.
REPEAT 348 377 WD 6.
REPEAT 389 419 WD 7. |
Keyword | 3D-structure; Complete proteome; Pheromone response; Reference proteome; Repeat; Transducer; WD repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 423 AA |
Protein Sequence | MAAHQMDSIT YSNNVTQQYI QPQSLQDISA VEDEIQNKIE AARQESKQLH AQINKAKHKI 60
QDASLFQMAN KVTSLTKNKI NLKPNIVLKG HNNKISDFRW SRDSKRILSA SQDGFMLIWD 120
SASGLKQNAI PLDSQWVLSC AISPSSTLVA SAGLNNNCTI YRVSKENRVA QNVASIFKGH 180
TCYISDIEFT DNAHILTASG DMTCALWDIP KAKRVREYSD HLGDVLALAI PEEPNSENSS 240
NTFASCGSDG YTYIWDSRSP SAVQSFYVND SDINALRFFK DGMSIVAGSD NGAINMYDLR 300
SDCSIATFSL FRGYEERTPT PTYMAANMEY NTAQSPQTLK STSSSYLDNQ GVVSLDFSAS 360
GRLMYSCYTD IGCVVWDVLK GEIVGKLEGH GGRVTGVRSS PDGLAVCTGS WDSTMKIWSP 420
GYQ 423 |
Gene Ontology | GO:0005834; C:heterotrimeric G-protein complex; IDA:SGD. GO:0005937; C:mating projection; IDA:SGD. GO:0004871; F:signal transducer activity; IMP:SGD. GO:0031684; P:heterotrimeric G-protein complex cycle; IMP:SGD. GO:0001403; P:invasive growth in response to glucose limitation; IMP:SGD. GO:0000750; P:pheromone-dependent signal transduction involved in conjugation with cellular fusion; IPI:SGD. GO:0010525; P:regulation of transposition, RNA-mediated; IMP:SGD. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |