UniProt Accession

 COQ4_HUMAN; Q9Y3A0; A8WBK8; B2R958; Q5T4B8; Q96EW4 

Genbank Protein ID

 EU216419; EU216420; EU216421; EU216422; EU216423; AF151850; AK313650; AL359091; CH471090; BC011895 

Genbank Nucleotide ID

 ABW91141.1; ABW91142.1; ABW91143.1; ABW91144.1; ABW91145.1; AAD34087.1; BAG36405.1; CAI13487.1; EAW87776.1; AAH11895.1 

Protein Name

 Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial 

Protein Synonyms/Alias

 Coenzyme Q biosynthesis protein 4 homolog 

Gene Name

 COQ4 

Gene Synonyms/Alias

 CGI-92 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
114	TSTLDLGKLQSLPEG	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides. 

Sequence Annotation

  

Keyword

 Alternative splicing; Complete proteome; Membrane; Mitochondrion; Mitochondrion inner membrane; Polymorphism; Reference proteome; Transit peptide; Ubiquinone biosynthesis. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 265 AA 

Protein Sequence

Gene Ontology

 GO:0031314; C:extrinsic to mitochondrial inner membrane; IEA:HAMAP.
 GO:0005739; C:mitochondrion; IDA:LIFEdb.
 GO:0006744; P:ubiquinone biosynthetic process; IEA:HAMAP. 

Interpro

 IPR007715; Coq4.
 IPR027540; Coq4_euk. 

Pfam

 PF05019; Coq4 

SMART

  

PROSITE

  

PRINTS