CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030900
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Medium-chain-specific acyl-CoA dehydrogenase, mitochondrial 
Protein Synonyms/Alias
 cDNA FLJ52595, highly similar to Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (EC 1.3.99.3) 
Gene Name
 ACADM 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
23ARSDPDPKAPANKAFacetylation[1]
28DPKAPANKAFTGFIVubiquitination[2, 3]
47PGIQIGRKELNMGQRubiquitination[2]
67GIVFEDVKVPKENVLacetylation[4]
67GIVFEDVKVPKENVLubiquitination[2, 3]
70FEDVKVPKENVLIGDubiquitination[2]
90VAMGAFDKTRPVVAAacetylation[1, 4]
90VAMGAFDKTRPVVAAubiquitination[2]
112RALDEATKYALERKTacetylation[4]
112RALDEATKYALERKTubiquitination[2, 3]
206EKLMRDAKIYQIYEGubiquitination[2, 3]
Reference
 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 232 AA 
Protein Sequence
MWITNGGKAN WYFLLARSDP DPKAPANKAF TGFIVEADTP GIQIGRKELN MGQRCSDTRG 60
IVFEDVKVPK ENVLIGDGAG FKVAMGAFDK TRPVVAAGAV GLAQRALDEA TKYALERKTF 120
GKLLVEHQAI SFMLAEMAMK VELARMSYQR AAWEVDSGRR NTYYASIAKA FAGDIANQLA 180
TDAVQILGGN GFNTEYPVEK LMRDAKIYQI YEGTSQIQRL IVAREHIDKY KN 232 
Gene Ontology
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0070991; F:medium-chain-acyl-CoA dehydrogenase activity; IEA:Compara.
 GO:0055007; P:cardiac muscle cell differentiation; IEA:Compara.
 GO:0019254; P:carnitine metabolic process, CoA-linked; IEA:Compara.
 GO:0033539; P:fatty acid beta-oxidation using acyl-CoA dehydrogenase; IEA:Compara.
 GO:0005978; P:glycogen biosynthetic process; IEA:Compara.
 GO:0001889; P:liver development; IEA:Compara.
 GO:0051791; P:medium-chain fatty acid metabolic process; IEA:Compara.
 GO:0009791; P:post-embryonic development; IEA:Compara.
 GO:0006111; P:regulation of gluconeogenesis; IEA:Compara.
 GO:0009409; P:response to cold; IEA:Compara.
 GO:0042594; P:response to starvation; IEA:Compara. 
Interpro
 IPR006089; Acyl-CoA_DH_CS.
 IPR006090; Acyl-CoA_Oxase/DH_1.
 IPR006091; Acyl-CoA_Oxase/DH_cen-dom.
 IPR009075; AcylCo_DH/oxidase_C.
 IPR009100; AcylCoA_DH/oxidase. 
Pfam
 PF00441; Acyl-CoA_dh_1 
SMART
  
PROSITE
 PS00073; ACYL_COA_DH_2 
PRINTS