CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025857
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Chromosome-associated kinesin KIF4A variant 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
996ENEIIKQKLTLLQVAubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Microtubule; Motor protein; Nucleotide-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1235 AA 
Protein Sequence
DRIMKEEVKG IPVRVALRCR PLVPKEISEG CQMCLSFVPG EPQVVVGTDK SFTYDFVFDP 60
STEQEEVFNT AVAPLIKGVF KGYNATVLAY GQTGSGKTYS MGGAYTAEQE NEPTVGVIPR 120
VIQLLFKEID KKSDFEFTLK VSYLEIYNEE ILDLLCPSRE KAQINIREDP KEGIKIVGLT 180
EKTVLVALDT VSCLEQGNNS RTVASTAMNS QSSRSHAIFT ISLEQRKKSD KNSSFRSKLH 240
LVDLAGSERQ KKTKAEGDRL KEGININRGL LCLGNVISAL GDDKKGGFVP YRDSKLTRLL 300
QDSLGGNSHT LMIACVSPAD SNLEETLNTL RYADRARKIK NKPIVNIDPQ TAELNHLKQQ 360
VQQLQVLLLQ AHGGTLPGSI TVEPSENLQS LMEKNQSLVE ENEKLSRGLS EAAGQTAQML 420
ERIIWTEQAN EKMNAKLEEL RQHAACKLDL QKLVETLEDQ ELKENVEIIC NLQQLITQLS 480
DETVACMAAA IDTAVEQEAQ VETSPETSRS SDAFTTQHAL RQAQMSKELV ELNKALALKE 540
ALARKMTQND SQLQPIQYQY QDNIKELELE VINLQKEKEE LVLELQTAKK DANQAKLSER 600
RRKRLQELEG QIADLKKKLN EQSKLLKLKE STERTVSKLN QEIRMMKNQR VQLMRQMKED 660
AEKFRQWKQK KDKEVIQLKE RDRKRQYELL KLERNFQKQS NVLRRKTEEA AAANKRLKDA 720
LQKQREVADK RKETQSRGME GTAARVKNWL GNEIEVMVST EEAKRHLNDL LEDRKILAQD 780
VAQLKEKKES GENPPPKLRR RTFSLTEVRG QVSESEDSIT KQIESLETEM EFRSAQIADL 840
QQKLLDAESE DRPKQRWENI ATILEAKCAL KYLIGELVSS KIQVSKLESS LKQSKTSCAD 900
MQKMLFEERN HFAEIETELQ AELVRMEQQH QEKVLYLLSQ LQQSQMAEKQ LEESVSEKEQ 960
QLLSTLKCQD EELEKMREVC EQNQQLLREN EIIKQKLTLL QVASRQKHLP KDTLLSPDSS 1020
FEYVPPKPKP SRVKEKFLEQ SMDIEDLKYC SEHSVNEHED GDGDDDEGDD EEWKPTKLVK 1080
VSRKNIQGCS CKGWCGNKQC GCRKQKSDCG VDCCCDPTKC RNRQQGKDSL GTVERTQDSE 1140
GSFKLEDPTE VTPGLSFFNP VCATPNSKIL KEMCDVEQVL SKKTPPAPSP FDLPELKHVA 1200
TEYQENKAPG KKKKRALASN TSFFSGCSPI EEEAH 1235 
Gene Ontology
 GO:0005694; C:chromosome; IEA:InterPro.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005875; C:microtubule associated complex; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003777; F:microtubule motor activity; IEA:InterPro.
 GO:0007018; P:microtubule-based movement; IEA:InterPro. 
Interpro
 IPR027327; KIF4.
 IPR019821; Kinesin_motor_CS.
 IPR001752; Kinesin_motor_dom.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00225; Kinesin 
SMART
 SM00129; KISc 
PROSITE
 PS00411; KINESIN_MOTOR_DOMAIN1
 PS50067; KINESIN_MOTOR_DOMAIN2 
PRINTS
 PR00380; KINESINHEAVY.