UniProt Accession

 PDK3_HUMAN; Q15120; B4DXG6 

Genbank Protein ID

 L42452; AK301965; CH471074; BC015948 

Genbank Nucleotide ID

 AAC42011.1; BAG63378.1; EAW99019.1; AAH15948.1 

Protein Name

 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial 

Protein Synonyms/Alias

 Pyruvate dehydrogenase kinase isoform 3 

Gene Name

 PDK3 

Gene Synonyms/Alias

 PDHK3 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
30	SPSPLSIKQFLDFGR	ubiquitination	[1]

Reference

 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species. 

Sequence Annotation

 DOMAIN 131 362 Histidine kinase.
 NP_BIND 247 254 ATP.
 NP_BIND 306 307 ATP.
 NP_BIND 323 328 ATP.
 BINDING 287 287 ATP.  

Keyword

 3D-structure; Alternative splicing; ATP-binding; Carbohydrate metabolism; Complete proteome; Glucose metabolism; Kinase; Mitochondrion; Nucleotide-binding; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 406 AA 

Protein Sequence

Gene Ontology

 GO:0005759; C:mitochondrial matrix; TAS:Reactome.
 GO:0005524; F:ATP binding; IDA:UniProtKB.
 GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
 GO:0004740; F:pyruvate dehydrogenase (acetyl-transferring) kinase activity; IDA:UniProtKB.
 GO:0071398; P:cellular response to fatty acid; IMP:UniProtKB.
 GO:0071333; P:cellular response to glucose stimulus; ISS:UniProtKB.
 GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
 GO:0097411; P:hypoxia-inducible factor-1alpha signaling pathway; IMP:UniProtKB.
 GO:0018105; P:peptidyl-serine phosphorylation; IDA:UniProtKB.
 GO:0035357; P:peroxisome proliferator activated receptor signaling pathway; IMP:UniProtKB.
 GO:0006090; P:pyruvate metabolic process; TAS:Reactome.
 GO:0010510; P:regulation of acetyl-CoA biosynthetic process from pyruvate; IMP:UniProtKB.
 GO:0010906; P:regulation of glucose metabolic process; IMP:UniProtKB.
 GO:2000377; P:regulation of reactive oxygen species metabolic process; IMP:UniProtKB. 

Interpro

 IPR018955; BCDHK/PDK_N.
 IPR003594; HATPase_ATP-bd.
 IPR005467; Sig_transdc_His_kinase_core. 

Pfam

 PF10436; BCDHK_Adom3
 PF02518; HATPase_c 

SMART

 SM00387; HATPase_c 

PROSITE

 PS50109; HIS_KIN 

PRINTS