UniProt Accession

 PEX7_HUMAN; O00628 

Genbank Protein ID

 U88871; U76560; AF180814; AF180806; AF180807; AF180808; AF180809; AF180810; AF180811; AF180812; AF180813; BC006268 

Genbank Nucleotide ID

 AAC51238.1; AAB50556.1; AAF37350.1; AAF37350.1; AAF37350.1; AAF37350.1; AAF37350.1; AAF37350.1; AAF37350.1; AAF37350.1; AAF37350.1; AAH06268.1 

Protein Name

 Peroxisomal targeting signal 2 receptor 

Protein Synonyms/Alias

 PTS2 receptor; Peroxin-7 

Gene Name

 PEX7 

Gene Synonyms/Alias

 PTS2R 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
186	TLRIWDVKAAGVRIV	ubiquitination	[1, 2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import. 

Sequence Annotation

 REPEAT 65 96 WD 1.
 REPEAT 109 141 WD 2.
 REPEAT 153 184 WD 3.
 REPEAT 196 227 WD 4.
 REPEAT 240 271 WD 5.
 REPEAT 284 315 WD 6.  

Keyword

 Cataract; Complete proteome; Cytoplasm; Deafness; Disease mutation; Ichthyosis; Peroxisome; Peroxisome biogenesis disorder; Polymorphism; Protein transport; Reference proteome; Repeat; Retinitis pigmentosa; Rhizomelic chondrodysplasia punctata; Transport; WD repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 323 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0005782; C:peroxisomal matrix; IDA:UniProtKB.
 GO:0005053; F:peroxisome matrix targeting signal-2 binding; IDA:UniProtKB.
 GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
 GO:0001958; P:endochondral ossification; IEA:Compara.
 GO:0008611; P:ether lipid biosynthetic process; IMP:UniProtKB.
 GO:0006635; P:fatty acid beta-oxidation; IEA:Compara.
 GO:0001764; P:neuron migration; IEA:Compara.
 GO:0016558; P:protein import into peroxisome matrix; IMP:UniProtKB. 

Interpro

 IPR020472; G-protein_beta_WD-40_rep.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 

Pfam

 PF00400; WD40 

SMART

 SM00320; WD40 

PROSITE

 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 

PRINTS

 PR00320; GPROTEINBRPT.