CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013525
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Chromosomal replication initiator protein DnaA 
Protein Synonyms/Alias
  
Gene Name
 dnaA 
Gene Synonyms/Alias
 MPN_686; MP156 
Created Date
 July 27, 2013 
Organism
 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
NCBI Taxa ID
 272634 
Lysine Modification
Position
Peptide
Type
References
108LSKNFTFKNFVVGDGacetylation[1]
Reference
 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819] 
Functional Description
 Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity). 
Sequence Annotation
 NP_BIND 141 148 ATP (Potential).  
Keyword
 ATP-binding; Complete proteome; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 439 AA 
Protein Sequence
MEQFSAFKLL LKKQYETTLG FYDKYIKNLK RFALKNNVLF VIVDNEFARE TLNSNPDIVG 60
LASKLYDDIR AVRFVNEQDF FINLAKLEED NRETLYQSSG LSKNFTFKNF VVGDGNRRVY 120
EAGVRISETQ DADFSPLFIY GETGLGKTHL LQAIGNDKFF HFPNAKVKYV VSSDFAQEVV 180
NAFYQKEKDQ GIEKLKAAYE SLDLLLIDDT QIFGKKEKTL EILFSIFNNL VSKGKQIVFV 240
SDKTPDELAN IDPRMVSRFK SGLLLKIEKH NLSSLCEILA VKLKEKDPNI QITNEAREKA 300
AQISGNDVRS LNGIATKLLF YVKTTKQNLI NNDNLKEILF EEFEKFHKKS FDPYLLIENV 360
CRRFNVPVDS VLSENRKAEL VRVRDVCNYI LREKYKMQFQ QIGKIFKRNH STVVAAVKRV 420
AKMIEKDDSL QDIITSLVI 439 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:HAMAP.
 GO:0003688; F:DNA replication origin binding; IEA:HAMAP.
 GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.
 GO:0006270; P:DNA replication initiation; IEA:HAMAP.
 GO:0006275; P:regulation of DNA replication; IEA:HAMAP. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR001957; Chromosome_initiator_DnaA.
 IPR020591; Chromosome_initiator_DnaA-like.
 IPR018312; Chromosome_initiator_DnaA_CS.
 IPR013159; DnaA_C.
 IPR013317; DnaA_Hda.
 IPR024633; DnaA_N_dom.
 IPR015946; KH_dom-like_a/b.
 IPR027417; P-loop_NTPase.
 IPR010921; Trp_repressor/repl_initiator. 
Pfam
 PF00308; Bac_DnaA
 PF08299; Bac_DnaA_C
 PF11638; DnaA_N 
SMART
 SM00382; AAA
 SM00760; Bac_DnaA_C 
PROSITE
 PS01008; DNAA 
PRINTS
 PR00051; DNAA.