UniProt Accession

 CRBB2_BOVIN; P02522 

Genbank Protein ID

 M22466 

Genbank Nucleotide ID

 AAA30472.1 

Protein Name

 Beta-crystallin B2 

Protein Synonyms/Alias

 Beta-B2 crystallin; Beta-crystallin Bp 

Gene Name

 CRYBB2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Bos taurus (Bovine) 

NCBI Taxa ID

 9913 

Lysine Modification

Position	Peptide	Type	References
11	DHQTQAGKPQPLNPK	glycation	[1]
48	LKETGVEKAGSVLVQ	glycation	[1]
68	GYEQANCKGEQFVFE	glycation	[1]
76	GEQFVFEKGEYPRWD	glycation	[1]
101	LSSLRPIKVDSQEHK	glycation	[1]
108	KVDSQEHKITLYENP	glycation	[1]
120	ENPNFTGKKMEVIDD	glycation	[1]
121	NPNFTGKKMEVIDDD	glycation	[1]
140	HAHGYQEKVSSVRVQ	glycation	[1]
168	GLQYLLEKGDYKDSG	glycation	[1]
172	LLEKGDYKDSGDFGA	glycation	[1]

Reference

 [1] Sites of glycation of beta B2-crystallin by glucose and fructose.
 Zhao HR, Smith JB, Jiang XY, Abraham EC.
 Biochem Biophys Res Commun. 1996 Dec 4;229(1):128-33. [PMID: 8954094] 

Functional Description

 Crystallins are the dominant structural components of the vertebrate eye lens. 

Sequence Annotation

 DOMAIN 17 56 Beta/gamma crystallin 'Greek key' 1.
 DOMAIN 57 101 Beta/gamma crystallin 'Greek key' 2.
 DOMAIN 107 148 Beta/gamma crystallin 'Greek key' 3.
 DOMAIN 149 191 Beta/gamma crystallin 'Greek key' 4.
 REGION 2 16 N-terminal arm.
 REGION 102 106 Connecting peptide.
 REGION 193 205 C-terminal arm.
 MOD_RES 2 2 N-acetylalanine.
 CARBOHYD 11 11 N-linked (Glc) (glycation); in vitro.
 CARBOHYD 48 48 N-linked (Glc) (glycation); in vitro.
 CARBOHYD 68 68 N-linked (Glc) (glycation); in vitro.
 CARBOHYD 76 76 N-linked (Glc) (glycation); in vitro.
 CARBOHYD 101 101 N-linked (Glc) (glycation); in vitro.
 CARBOHYD 108 108 N-linked (Glc) (glycation); in vitro.
 CARBOHYD 120 120 N-linked (Glc) (glycation); in vitro.
 CARBOHYD 121 121 N-linked (Glc) (glycation); in vitro.
 CARBOHYD 140 140 N-linked (Glc) (glycation); in vitro.
 CARBOHYD 168 168 N-linked (Glc) (glycation); in vitro.
 CARBOHYD 172 172 N-linked (Glc) (glycation); in vitro.  

Keyword

 3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Eye lens protein; Glycation; Glycoprotein; Oxidation; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 205 AA 

Protein Sequence

Gene Ontology

 GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW.
 GO:0043010; P:camera-type eye development; IEA:Compara.
 GO:0007601; P:visual perception; IEA:Compara. 

Interpro

 IPR001064; Beta/gamma_crystallin.
 IPR011024; G_crystallin-rel. 

Pfam

 PF00030; Crystall 

SMART

 SM00247; XTALbg 

PROSITE

 PS50915; CRYSTALLIN_BETA_GAMMA 

PRINTS

 PR01367; BGCRYSTALLIN.