UniProt Accession

 DCLK1_HUMAN; O15075; B7Z3E9; Q5VZY8; Q5VZZ0; Q5VZZ1 

Genbank Protein ID

 AB002367; AL157760; AL157694; AL160392; AL390029; AL157760; AK295777; AL157760; AL157694; AL160392; AL390029; AL160392; AL157694; AL157760; AL390029; AL160392; AL157694; AL157760; AL390029; AL157694; AL157760; AL160392; AL390029; AL157694; AL157760; AL160392; AL390029; AL390029; AL157694; AL157760; AL160392; AL390029; AL157694; AL157760; AL160392; CH471075; CH471075; BC152456 

Genbank Nucleotide ID

 BAA20824.2; CAH70167.1; CAH70167.1; CAH70167.1; CAH70167.1; CAH70170.1; BAH12185.1; CAH70168.1; CAH70168.1; CAH70168.1; CAH70168.1; CAH70261.1; CAH70261.1; CAH70261.1; CAH70261.1; CAH70262.1; CAH70262.1; CAH70262.1; CAH70262.1; CAH70656.1; CAH70656.1; CAH70656.1; CAH70656.1; CAH70657.1; CAH70657.1; CAH70657.1; CAH70657.1; CAI15720.1; CAI15720.1; CAI15720.1; CAI15720.1; CAI15721.1; CAI15721.1; CAI15721.1; CAI15721.1; EAX08550.1; EAX08551.1; AAI52457.1 

Protein Name

 Serine/threonine-protein kinase DCLK1 

Protein Synonyms/Alias

 Doublecortin domain-containing protein 3A; Doublecortin-like and CAM kinase-like 1; Doublecortin-like kinase 1 

Gene Name

 DCLK1 

Gene Synonyms/Alias

 DCAMKL1; DCDC3A; KIAA0369 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
280	ESECRVVKSTSYTKI	ubiquitination	[1, 2]
286	VKSTSYTKIASSSRR	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Probable kinase that may be involved in a calcium- signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system. 

Sequence Annotation

 DOMAIN 57 143 Doublecortin 1.
 DOMAIN 186 269 Doublecortin 2.
 DOMAIN 390 647 Protein kinase.
 NP_BIND 396 404 ATP (By similarity).
 ACT_SITE 511 511 Proton acceptor (By similarity).
 BINDING 419 419 ATP (By similarity).
 MOD_RES 32 32 Phosphoserine (By similarity).
 MOD_RES 36 36 Phosphoserine (By similarity).
 MOD_RES 305 305 Phosphoserine (By similarity).
 MOD_RES 307 307 Phosphoserine (By similarity).
 MOD_RES 330 330 Phosphoserine (By similarity).
 MOD_RES 332 332 Phosphoserine (By similarity).
 MOD_RES 336 336 Phosphothreonine (By similarity).
 MOD_RES 337 337 Phosphoserine (By similarity).
 MOD_RES 352 352 Phosphoserine.
 MOD_RES 364 364 Phosphoserine (By similarity).
 MOD_RES 376 376 Phosphoserine (By similarity).
 MOD_RES 493 493 Phosphotyrosine (By similarity).
 MOD_RES 520 520 Phosphotyrosine (By similarity).
 MOD_RES 722 722 Phosphoserine (By similarity).
 MOD_RES 726 726 Phosphoserine (By similarity).  

Keyword

 3D-structure; Alternative splicing; ATP-binding; Complete proteome; Developmental protein; Differentiation; Kinase; Neurogenesis; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 740 AA 

Protein Sequence

Gene Ontology

 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004672; F:protein kinase activity; TAS:ProtInc.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
 GO:0005057; F:receptor signaling protein activity; TAS:ProtInc.
 GO:0048675; P:axon extension; IEA:Compara.
 GO:0007417; P:central nervous system development; TAS:ProtInc.
 GO:0021952; P:central nervous system projection neuron axonogenesis; IEA:Compara.
 GO:0048813; P:dendrite morphogenesis; IEA:Compara.
 GO:0016197; P:endosomal transport; NAS:UniProtKB.
 GO:0030900; P:forebrain development; IEA:Compara.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0001764; P:neuron migration; IEA:Compara.
 GO:0009615; P:response to virus; IEP:UniProtKB. 

Interpro

 IPR020636; Ca/CaM-dep_Ca-dep_prot_Kinase.
 IPR003533; Doublecortin_dom.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 

Pfam

 PF03607; DCX
 PF00069; Pkinase 

SMART

 SM00537; DCX
 SM00220; S_TKc 

PROSITE

 PS50309; DC
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 

PRINTS